Promazine

Source: Wikipedia, the free encyclopedia.
Not to be confused with Bromazine.
Promazine
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
MedlinePlusa600010
Drug classTypical antipsychotic
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding94%
Elimination half-life20-40 hr
Identifiers
  • N,N-dimethyl-3-(10H-phenothiazin-10-yl)-propan-1-amine
JSmol)
  • CN(C)CCCN1c2ccccc2Sc3c1cccc3
  • InChI=1S/C17H20N2S/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19/h3-6,8-11H,7,12-13H2,1-2H3 checkY
  • Key:ZGUGWUXLJSTTMA-UHFFFAOYSA-N checkY
  (verify)

Promazine (brand name Sparine among others),

psychoses.[3]

It acts similar to chlorpromazine and causes sedation.[3] It has predominantly anticholinergic side effects, though extrapyramidal side effects are not uncommon. It belongs to the typical antipsychotic and phenothiazine class of drugs.[5]

Promazine was approved for medical use in the United States in the 1950s, although it is no longer commercially available there.[2][6]

Uses

Promazine is a short-term add-on treatment for psychomotor agitation.[4]

Adverse effects

Common side effects include agitation,

high sugars, difficulty sleeping, low blood pressure, prolonged QT, fits, shaking, vomiting and weight gain, among others.[4]

Overdose

In overdose, it may cause blood pressure to drop, lowering of body temperature, increased heart rate, and an irregular heart beat.[4]

Sudden death may occur, although rare.[4]

Other animals

Promazine, given as promazine hydrochloride, is one of the primary tranquilizers used by veterinarians as a pre-anaesthesia injection in horses.

kidney failure.[8] It is available in the US for veterinary use under the names Promazine and Tranquazine.[citation needed
]

Synthesis

Synthesis:[10][11][12] Patents:[13][14] ~75%:[15]

References

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ a b "Promazine (Primazine, Prozine)". Davis's Drug Guide. Retrieved 6 August 2021.
  3. ^
    ISBN 978-0-08-055232-3
    .
  4. ^ a b c d e "BNF". NICE. Retrieved 4 August 2021.
  5. ISBN 978-1-138-00968-4
    .
  6. ^ "Drugs@FDA: FDA-Approved Drugs". New Drug Application (NDA): 010942 Sparine. U.S. Food and Drug Administration.
  7. ^
    ISBN 978-0-7817-8255-5
    .
  8. ^ a b c d "Promazine". Equimed - Horse Health Matters. 20 January 2014. Archived from the original on 4 August 2021. Retrieved 4 August 2021.
  9. ^
    ISBN 978-0-323-48420-6
    .
  10. PMID 13584240
    .
  11. doi:10.1021/jo01292a048
    .
  12. S2CID 95682513
    .
  13. ^ US 2519886, Charpentier P, issued 1950, assigned to Rhône-Poulenc. 
  14. ^ US 3100772, Kantor ML, Samuel T, issued 1963, assigned to Wyeth LLC. 
  15. PMID 18213669
    .