Cyclin D3
G1/S-specific cyclin-D3 is a protein that in humans is encoded by the CCND3 gene.[5]
Function
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation.[6]
Clinical significance
Mutations in CCND3 are implicated in cases of breast cancer.[7]
Interactions
Cyclin D3 has been shown to
interact
with:
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000112576 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034165 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1386335.
- ^ "Entrez Gene: CCND3 cyclin D3".
- PMID 23000897.
- ^ PMID 14641107.
- PMID 12082095.
- ^ S2CID 4427026.
- ^ PMID 11360184.
- ^ PMID 10342870.
- ^ PMID 12482873.
- PMID 8114739.
- S2CID 16005938.
Further reading
- Motokura T, Keyomarsi K, Kronenberg HM, Arnold A (1992). "Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene". J. Biol. Chem. 267 (28): 20412–5. PMID 1383201.
- Xiong Y, Menninger J, Beach D, Ward DC (1992). "Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins". Genomics. 13 (3): 575–84. PMID 1386336.
- Motokura T, Yi HF, Kronenberg HM, McBride OW, Arnold A (1992). "Assignment of the human cyclin D3 gene (CCND3) to chromosome 6p----q13". Cytogenet. Cell Genet. 61 (1): 5–7. PMID 1387066.
- Matsuoka S, Yamaguchi M, Matsukage A (1994). "D-type cyclin-binding regions of proliferating cell nuclear antigen". J. Biol. Chem. 269 (15): 11030–6. PMID 7908906.
- Meyerson M, Harlow E (1994). "Identification of G1 kinase activity for cdk6, a novel cyclin D partner". Mol. Cell. Biol. 14 (3): 2077–86. PMID 8114739.
- Dowdy SF, Hinds PW, Louie K, Reed SI, Arnold A, Weinberg RA (1993). "Physical interaction of the retinoblastoma protein with human D cyclins". Cell. 73 (3): 499–511. S2CID 24708871.
- Brooks AR, Shiffman D, Chan CS, Brooks EE, Milner PG (1996). "Functional analysis of the human cyclin D2 and cyclin D3 promoters". J. Biol. Chem. 271 (15): 9090–9. PMID 8621559.
- Tiefenbrun N, Melamed D, Levy N, Resnitzky D, Hoffman I, Reed SI, Kimchi A (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. PMID 8668211.
- Hirai H, Sherr CJ (1996). "Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1". Mol. Cell. Biol. 16 (11): 6457–67. PMID 8887674.
- Doglioni C, Chiarelli C, Macrí E, Dei Tos AP, Meggiolaro E, Dalla Palma P, Barbareschi M (1998). "Cyclin D3 expression in normal, reactive and neoplastic tissues". J. Pathol. 185 (2): 159–66. S2CID 38572590.
- Gómez Lahoz E, Liegeois NJ, Zhang P, Engelman JA, Horner J, Silverman A, Burde R, Roussel MF, Sherr CJ, Elledge SJ, DePinho RA (1999). "Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo". Mol. Cell. Biol. 19 (1): 353–63. PMID 9858559.
- Gabrielli BG, Sarcevic B, Sinnamon J, Walker G, Castellano M, Wang XQ, Ellem KA (1999). "A cyclin D-Cdk4 activity required for G2 phase cell cycle progression is inhibited in ultraviolet radiation-induced G2 phase delay". J. Biol. Chem. 274 (20): 13961–9. PMID 10318807.
- Zhang Q, Wang X, Wolgemuth DJ (1999). "Developmentally regulated expression of cyclin D3 and its potential in vivo interacting proteins during murine gametogenesis". Endocrinology. 140 (6): 2790–800. PMID 10342870.
- Bartkova J, Rajpert-de Meyts E, Skakkebaek NE, Bartek J (1999). "D-type cyclins in adult human testis and testicular cancer: relation to cell type, proliferation, differentiation, and malignancy". J. Pathol. 187 (5): 573–81. S2CID 9474072.
- Jones CJ, Kipling D, Morris M, Hepburn P, Skinner J, Bounacer A, Wyllie FS, Ivan M, Bartek J, Wynford-Thomas D, Bond JA (2000). "Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells". Mol. Cell. Biol. 20 (15): 5690–9. PMID 10891505.
- Sansal I, Dupont E, Toru D, Evrard C, Rouget P (2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity". Oncogene. 19 (43): 5000–9. PMID 11042687.
- Fink JR, LeBien TW (2001). "Novel expression of cyclin-dependent kinase inhibitors in human B-cell precursors". Exp. Hematol. 29 (4): 490–8. PMID 11301189.
- Lin J, Jinno S, Okayama H (2001). "Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence". Oncogene. 20 (16): 2000–9. PMID 11360184.
- Bartkova J, Thullberg M, Slezak P, Jaramillo E, Rubio C, Thomassen LH, Bartek J (2001). "Aberrant expression of G1-phase cell cycle regulators in flat and exophytic adenomas of the human colon". Gastroenterology. 120 (7): 1680–8. PMID 11375949.