Cullin
| Cullin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Cullin protein neddylation domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 structure of the cul1-rbx1-skp1-f boxskp2 scf ubiquitin ligase complex | |||||||||
| Identifiers | |||||||||
| Symbol | Cullin_Nedd8 | ||||||||
| Pfam | PF10557 | ||||||||
| InterPro | IPR019559 | ||||||||
| |||||||||
Cullins are a family of hydrophobic
The human genome contains eight cullin genes
- CUL1, part of SCF complex
- Elongin C - CUL2 - SOCS-box)
- CUL3, part of CUL3-BTB complex
- CUL4A
- CUL4B
- CUL5
- CUL7
- CUL9, also known as PARC
There is also a more distant member called ANAPC2 (or APC2), part of the Anaphase-promoting complex.
CUL1, 2, 3, 4A, 4B, 5 and 7 each form part of a multi-subunit ubiquitin complex.
Cullin-RING ubiquitin ligases
Cullin-RING ubiquitin
Modification by NEDD8
With the exception of ANAPC2, each member of the cullin family is modified by
References
External links
- Cullin family - Sanger Institutewebsite.
- Cullin+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)