Cysteine—tRNA ligase
| Cysteine—tRNA ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In
- ATP + L-cysteine + tRNACys AMP + diphosphate + L-cysteinyl-tRNACys
The 3
diphosphate, and L-cysteinyl-tRNA(Cys)
.
This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-cysteine:tRNACys ligase (AMP-forming). Other names in common use include cysteinyl-tRNA synthetase, cysteinyl-transferRNA synthetase, cysteinyl-transfer ribonucleate synthetase, and cysteine translase. This enzyme participates in cysteine metabolism and aminoacyl-trna biosynthesis.
Structural studies
As of late 2007, 3
structures have been solved for this class of enzymes, with PDB accession codes 1LI5, 1LI7, and 1U0B
.
References
- Mccorquodale DJ (December 1964). "The separation and partial purification of aminoacyl-RNA synthetases from Escherichia coliI". Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects. 91 (4): 541–8. PMID 14262440.
