Carbamoyl phosphate synthase II

Carbamoyl-phosphate synthetase (glutamine-hydrolysing)
Identifiers
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

carbamoyl-phosphate synthetase 1, aspartate transcarbamylase, and dihydroorotase
Identifiers
Symbol	CAD
Chr. 2 p21
Search for Structures Swiss-model Domains InterPro

Carbamoyl phosphate synthetase (glutamine-hydrolysing) (

In pyrimidine biosynthesis, it serves as the rate-limiting enzyme and catalyzes the following reaction:

2 ATP + L-glutamine + HCO₃⁻ + H₂O ${\displaystyle \rightleftharpoons }$ 2 ADP +

glutamate + carbamoyl phosphate

(overall reaction)

(1a) L-glutamine + H₂O ${\displaystyle \rightleftharpoons }$ L-glutamate + NH₃

(1b) 2 ATP + HCO₃⁻ + NH₃ ${\displaystyle \rightleftharpoons }$ 2 ADP + phosphate + carbamoyl phosphate

It is activated by

Neither CPSI nor CPSII require biotin as a coenzyme, as seen with most carboxylation reactions.

It is one of the three enzyme functions coded by the

.

See also

• Carbamoyl phosphate synthetase I
• Carbamoyl phosphate synthetase III

References

External links

• Carbamoyl-Phosphate+Synthase+(Glutamine-Hydrolyzing) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This EC 6.3 enzyme-related article is a stub. You can help Wikipedia by expanding it.

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