GPVI
| GP6 | |||
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Gene ontology | |||
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| Sources:Amigo / QuickGO | |||
Ensembl |
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| Location (UCSC) | Chr 19: 55.01 – 55.04 Mb | Chr 7: 4.37 – 4.4 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Glycoprotein VI (platelet), also known as GPVI, is a
GPVI was first cloned in 2000 by several groups including that of Martine Jandrot-Perrus from INSERM.Function
Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the
atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke.[6][7]
Complete or partial deficiency of GPVI in humans is a rare condition presenting as a mild bleeding disorder.
Interactions
GPVI has been shown to
See also
References
- ^ a b c ENSG00000274050, ENSG00000278670, ENSG00000276211, ENSG00000277439, ENSG00000278316, ENSG00000275633, ENSG00000274566, ENSG00000275931, ENSG00000276065 GRCh38: Ensembl release 89: ENSG00000088053, ENSG00000274050, ENSG00000278670, ENSG00000276211, ENSG00000277439, ENSG00000278316, ENSG00000275633, ENSG00000274566, ENSG00000275931, ENSG00000276065 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000078810 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 11027634.
- ^ "Entrez Gene: GP6 glycoprotein VI (platelet)".
- PMID 10961879.
- PMID 11943772.
Further reading
- Nieswandt B, Watson SP (Jul 2003). "Platelet-collagen interaction: is GPVI the central receptor?". Blood. 102 (2): 449–61. PMID 12649139.
- Watson SP, Auger JM, McCarty OJ, Pearce AC (Aug 2005). "GPVI and integrin alphaIIb beta3 signaling in platelets". Journal of Thrombosis and Haemostasis. 3 (8): 1752–62. S2CID 42666713.
- Huang MM, Bolen JB, Barnwell JW, Shattil SJ, Brugge JS (Sep 1991). "Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets". Proceedings of the National Academy of Sciences of the United States of America. 88 (17): 7844–8. PMID 1715582.
- Moroi M, Jung SM, Okuma M, Shinmyozu K (Nov 1989). "A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion". The Journal of Clinical Investigation. 84 (5): 1440–5. PMID 2808700.
- Polgár J, Clemetson JM, Kehrel BE, Wiedemann M, Magnenat EM, Wells TN, Clemetson KJ (May 1997). "Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor". The Journal of Biological Chemistry. 272 (21): 13576–83. PMID 9153205.
- Gibbins JM, Okuma M, Farndale R, Barnes M, Watson SP (Aug 1997). "Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain". FEBS Letters. 413 (2): 255–9. S2CID 84145901.
- Tsuji M, Ezumi Y, Arai M, Takayama H (Sep 1997). "A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets". The Journal of Biological Chemistry. 272 (38): 23528–31. PMID 9295288.
- Clemetson JM, Polgar J, Magnenat E, Wells TN, Clemetson KJ (Oct 1999). "The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors". The Journal of Biological Chemistry. 274 (41): 29019–24. PMID 10506151.
- Miura Y, Ohnuma M, Jung SM, Moroi M (May 2000). "Cloning and expression of the platelet-specific collagen receptor glycoprotein VI". PMID 10822077.
- Nieswandt B, Bergmeier W, Schulte V, Rackebrandt K, Gessner JE, Zirngibl H (Aug 2000). "Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain". The Journal of Biological Chemistry. 275 (31): 23998–4002. PMID 10825177.
- PMID 10961879.
- Ezumi Y, Uchiyama T, Takayama H (Oct 2000). "Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI". Biochemical and Biophysical Research Communications. 277 (1): 27–36. PMID 11027634.
- Barry FA, Gibbins JM (Apr 2002). "Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI". The Journal of Biological Chemistry. 277 (15): 12874–8. PMID 11825911.
- Suzuki-Inoue K, Tulasne D, Shen Y, Bori-Sanz T, Inoue O, Jung SM, Moroi M, Andrews RK, Berndt MC, Watson SP (Jun 2002). "Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling". The Journal of Biological Chemistry. 277 (24): 21561–6. PMID 11943772.
- Quinton TM, Ozdener F, Dangelmaier C, Daniel JL, Kunapuli SP (May 2002). "Glycoprotein VI-mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP". Blood. 99 (9): 3228–34. PMID 11964287.
- Saving KL, Mankin PE, Gorman MJ (Feb 2002). "Differences in adhesion receptor expression between immature and older platelets and red blood cells of neonates and adults". Journal of Pediatric Hematology/Oncology. 24 (2): 120–4. S2CID 23735309.
- Andrews RK, Suzuki-Inoue K, Shen Y, Tulasne D, Watson SP, Berndt MC (Jun 2002). "Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI" (PDF). Blood. 99 (11): 4219–21. S2CID 11271161.
- Wonerow P, Obergfell A, Wilde JI, Bobe R, Asazuma N, Brdicka T, Leo A, Schraven B, Horejsí V, Shattil SJ, Watson SP (Jun 2002). "Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets". The Biochemical Journal. 364 (Pt 3): 755–65. PMID 12049640.
- Miura Y, Takahashi T, Jung SM, Moroi M (Nov 2002). "Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen". The Journal of Biological Chemistry. 277 (48): 46197–204. PMID 12356768.
- Holmes ML, Bartle N, Eisbacher M, Chong BH (Dec 2002). "Cloning and analysis of the thrombopoietin-induced megakaryocyte-specific glycoprotein VI promoter and its regulation by GATA-1, Fli-1, and Sp1". The Journal of Biological Chemistry. 277 (50): 48333–41. PMID 12359731.
External links
- GPVI+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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