Galactoside acetyltransferase
| Galactoside O-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| Thiogalactoside acetyltransferase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | lacA | ||||||
UniProt | P07464 | ||||||
| |||||||
Galactoside acetyltransferase (also known as Galactoside O-acetyltransferase, thiogalactoside transacetylase, β-galactoside transacetylase and GAT) is an
E. coli.[1]
Reaction
It catalyzes the following reaction:
acetyl-CoA + beta-D-galactoside → CoA + 6-acetyl-beta-D-galactoside
The kinetics of the enzyme were delineated in 1995.[2]
Biological role
The enzyme's role in the classical E.coli lac operon remains unclear.[1][3] However, the enzyme's cellular role may be to detoxify non-metabolizable pyranosides by acetylating them and preventing their reentry into the cell.[1][4]
See also
- Transacetylase
References
- ^ a b c
Wang XG, Olsen LR, Roderick SL (April 2002). "Structure of the lac operon galactoside acetyltransferase". Structure. 10 (4): 581–8. PMID 11937062.
- PMID 7592843.
- PMID 15950163.
- ^ "Thiogalactoside transacetylase of the lactose operon as an enzyme for detoxification". 1976.
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External links
Media related to Galactoside acetyltransferase at Wikimedia Commons- galactoside+acetyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- EC 2.3.1.18
