Iomazenil
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| Other names | Ro 16-0154 |
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JSmol) | |
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Iomazenil (also known as Ro16-0154,
GABAA receptors) in the brain. Iomazenil is an analogue of flumazenil (Ro15-1788).[1]
Use in brain research
123I-labelled iomazenil can be used to image
The effect of iomazenil of reducing levels of
GABA in the brain was used by researchers to exacerbate symptoms in patients with schizophrenia in a laboratory study, supporting the theory that a GABA deficiency underlies that disease.[4]
Alcohol treatment
Researchers at
drunkenness due to its ability to bind alcohol receptors in the brain.[5]
See also
References
External links
- The MICAD Research Team (2004). [123I]Iomazenil. US National Center for Biotechnology Information (NCBI). )
- Clinical trial number NCT00982982 for "Effects of Delta-9-THC and Iomazenil in Healthy Humans" at ClinicalTrials.gov
- Clinical trial number NCT01590277 for "Ability of Partial Inverse Agonist, Iomazenil, to Block Ethanol Effects in Humans" at ClinicalTrials.gov