Technetium (99mTc) exametazime

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Technetium (99mTc) exametazime
Clinical data
Trade namesCeretec
License data
Intravenous
ATC code
Legal status
Legal status
Identifiers
  • [[(3RS,3'RS)-3,3'-[(2,2-Dimethyltrimethylene)diimino][di-2-butanone]dioximato](3–)-N,N',N'',N''']oxotechnetium (99mTc)
JSmol)
Chiralityracemic
  • CC1(C)CN2[Tc]3(N4C1)([N](O[H]O[N]3=C(C)[C@H]4C)=C(C)[C@H]2C)=O

  • CC1(C)CN2[Tc]3(N4C1)([N](O[H]O[N]3=C(C)[C@@H]4C)=C(C)[C@@H]2C)=O
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Technetium (99mTc) exametazime is a

abdominal infections[2] and inflammatory bowel disease.[3] Exametazime (the part without technetium) is sometimes referred to as hexamethylpropylene amine oxime or HMPAO, although correct chemical names are:[4]

  • (NE)-N-[(3R)-3-[[3-[[(2R,3E)-3-hydroxyiminobutan-2-yl]amino]-2,2-dimethylpropyl]amino]butan-2-ylidene]hydroxylamine
  • or 3,3'-((2,2,-dimethyl-1,3-propanediyl)diimino)bis-2-butanone dioxime.

Chemistry

One of the two enantiomers of exametazime

The drug consists of exametazime as a

meso form
, is not included.

References

  1. S2CID 11934803
    .
  2. PMID 7489945
    .
  3. PMID 1804909
    .
  4. ^ "Exametazime". PubChem. National Institutes of Health.
  5. ^ "Monography in the European Pharmacopoeia" (PDF).

External links

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