Indium-111
| General | |
|---|---|
Decay mode | Decay energy (MeV) |
| EC | 0.860[2] |
| Isotopes of indium Complete table of nuclides | |
Indium-111 (111In) is a
cadmium-111 with a half-life of 2.8 days.[3]
Indium-111 chloride (111InCl) solution is produced by proton irradiation of a cadmium target (112Cd(p,2n) or 111Cd(p,n)) in a cyclotron, as recommended by International Atomic Energy Agency (IAEA).[4] The former method is more commonly used as it results in a high level of radionuclide purity.
Indium-111 is commonly used in
radiolabeling targeted molecules or cells. During its radioactive decay, it emits low energy gamma (γ) photons which can be imaged using planar or single-photon emission computed tomography (SPECT) gamma cameras (primary energies (ε) of 171.3 keV (91%) and 245.4 keV (94%))[3]
Uses in nuclear medicine
When formulated as an 111InCl solution, it can be used to bind
antibodies, peptides, or other molecular targeted proteins or other molecules, typically using a chelate to bind the radionuclide (in this case 111In) to the targeting molecule during the radiosynthesis/ radiolabeling
process, which is tailored to the desired product.
111In labeled antibodies
- Ibritumomab Tiuxetan; Zevalin - For dosimetry estimates prior to 90Y immunotherapy for lymphoma
- 111In ProstaScint — PSMA antibody imaging of prostate cancer
111In labeled peptides
- 111In pentetreotide (including in 111In (Octreoscan)
- Octreotide is an somatostatin receptor inhibitor pharmaceutical which binds with high affinity to somatostatin receptors 2 and 5, interfering with normal receptor function. It is used as a drug to treat several neuroendocrine tumors in which somatostatin receptors are overexpressed or overactive. Examples include:
- Sympathoadrenal system tumors: pheochromocytoma, neuroblastoma, ganglioneuroma, paraganglioma
- Gastroenteropancreatic (GEP) tumors: carcinoid, insulinoma
- Medullary thyroid cancer, pituitary adenoma, small cell lung cancer
- 111In pentetreotide imaging can identify the presence, levels of somatostatin receptor 2,5 expression, extent of disease and response to therapy
- Octreotide is an somatostatin receptor inhibitor pharmaceutical which binds with high affinity to somatostatin receptors 2 and 5, interfering with normal receptor function. It is used as a drug to treat several neuroendocrine tumors in which somatostatin receptors are overexpressed or overactive. Examples include:
111In can also be formulated in the chemical form 111In oxyquinoline (oxine)[5] for labeling blood cells and components
See also
- Isotopes of indium
- Indium white blood cell scan
References
- ISBN 92-822-2218-7. Retrieved 26 June 2017.
- .
- ^ a b "FDA Label Document:Indium In-111 Chloride Sterile Solution". www.accessdata.fda.gov. Retrieved 20 Aug 2018.
- ISSN 0168-583X.
- ^ "PubChem In-111 Oxyquinoline". pubchem.ncbi.nlm.nih.gov. Retrieved 20 Aug 2018.
- ^ "IN-111 FACT SHEET" (PDF). Nordion(Canada), Inc. Archived from the original (PDF) on 3 December 2011. Retrieved 23 September 2012.