Radiopharmacology

Source: Wikipedia, the free encyclopedia.
See also: Radiopharmaceutical
Radiopharmacology
Lead container for iodine-123 capsule
Other namesMedicinal radiochemistry
Specialtyoncology

Radiopharmacology is

tumors.[1]

The term radioisotope, which in its general

radioiodine
) are used directly as soluble ionic salts, without further modification. This use relies on the chemical and biological properties of the radioisotope itself, to localize it within the body.

History

See nuclear medicine.

Production

Production of a radiopharmaceutical involves two processes:

  • The production of the radionuclide on which the pharmaceutical is based.
  • The preparation and packaging of the complete radiopharmaceutical.

Radionuclides used in radiopharmaceuticals are mostly radioactive

isotopes of elements with atomic numbers less than that of bismuth
, that is, they are radioactive isotopes of elements that also have one or more stable isotopes. These may be roughly divided into two classes:

Practical use

Because radiopharmeuticals require special licenses and handling techniques, they are often kept in local centers for medical radioisotope storage, often known as

radiopharmacies. A radiopharmacist may dispense them from there, to local centers where they are handled at the practical medicine
facility.

Drug nomenclature for radiopharmaceuticals

As with other pharmaceutical drugs, there is

International Nonproprietary Name (INN) gives the base drug name, followed by the radioisotope (as mass number, no space, element symbol) in parentheses with no superscript, followed by the ligand (if any). It is common to see square brackets and superscript superimposed onto the INN name, because chemical nomenclature (such as IUPAC nomenclature) uses those. The United States Pharmacopeia (USP) name gives the base drug name, followed by the radioisotope (as element symbol, space, mass number) with no parentheses, no hyphen, and no superscript, followed by the ligand (if any). The USP style is not the INN style, despite their being described as one and the same in some publications (e.g., AMA,[4] whose style for radiopharmaceuticals matches the USP style). The United States Pharmacopeial Convention is a sponsor organization of the USAN Council, and the USAN
for a given drug is often the same as the USP name.

International Nonproprietary Name
(INN)		 United States Pharmacopeia (USP) Comments
technetium (99mTc) sestamibi technetium Tc 99m sestamibi  
fludeoxyglucose (18F)
 fludeoxyglucose F 18  
sodium iodide (125I) sodium iodide I 125  
indium (111In) altumomab pentetate indium In 111 altumomab pentetate  

See also

References

  1. ISBN 3-527-29496-1
  2. ^ "Canada's Chalk River Reactor coming back online will not solve long-term isotope shortage in hospitals, researchers say".
  3. ^ "Archived copy" (PDF). Archived from the original (PDF) on 2018-03-13. Retrieved 2014-09-21.{{cite web}}: CS1 maint: archived copy as title (link)
  4. ISBN 978-0-19-517633-9. {{citation}}: |first= has generic name (help)CS1 maint: multiple names: authors list (link
    )

Further reading

External links
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