Isoxsuprine

Source: Wikipedia, the free encyclopedia.
Isoxsuprine
Clinical data
Pronunciation/aɪˈsɒksjʊpriːn/
Trade namesDuvadilan, Vasodilan
MedlinePlusa682831
Routes of
administration		Oral (tablets)
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability~100% (humans),[1] 2.2% (horses; oral)[2]
Onset of action1 hour
Elimination half-life<3 hours (horses)[3]
ExcretionMainly renal
Identifiers
  • 4-{1-Hydroxy-2-[(1-methyl-2-phenoxyethyl)amino]propyl}phenol
JSmol)
  • O(c1ccccc1)CC(NC(C)C(O)c2ccc(O)cc2)C
  • InChI=1S/C18H23NO3/c1-13(12-22-17-6-4-3-5-7-17)19-14(2)18(21)15-8-10-16(20)11-9-15/h3-11,13-14,18-21H,12H2,1-2H3 checkY
  • Key:BMUKKTUHUDJSNZ-UHFFFAOYSA-N checkY

Isoxsuprine (used as isoxsuprine hydrochloride) is a drug used as a

equines. Isoxsuprine is a β2 adrenoreceptor agonist that causes direct relaxation of uterine and vascular smooth muscle via β2 receptors.[5]

Use

In humans

Isoxsuprine is used in humans for treatment of premature labor, i.e. a

Raynaud's phenomenon, and other conditions.[7]

Isoxsuprine may increase the heart rate, cause changes in blood pressure, and irritate the GI tract. It should therefore be used with caution if combined with other drugs that affect blood pressure, such as sedatives and anesthetic drugs.

In horses

Isoxsuprine is most commonly used to treat hoof-related problems in the horse, most commonly for

navicular disease, as its effects as a vasodilator are thought to increase circulation within the hoof to help counteract the problems associated with these conditions. Isoxsuprine is given orally, and many horses find the pills quite palatable.[8] Isoxsuprine is a prohibited class B drug in FEI
-regulated competition, and is often prohibited by other equine associations. It may be detected in the urine for several weeks or months following administration. It is therefore important to check the drug-rules within an animal's given competitive organization, before administering the drug.

Because it is a vasodilator, it should not be used in horses that are bleeding, or in mares following foaling.

References

  1. ISBN 978-0781728454
    .
  2. PMID 12000527
    .
  3. ISBN 978-0-8138-2262-4
    .
  4. PMID 6488912
    .
  5. S2CID 6039919
    .
  6. S2CID 21297911
    .
  7. ^ "Isoxsuprine". Drugs.com.
  8. OCLC 1360077554
    .
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