List of adverse effects of aripiprazole
The rates of adverse effects of aripiprazole are:[1][2][3][4][5]
Adults
Very common (>10% incidence)
- Weight gain
- Headache
- Agitation
- Insomnia
- Anxiety
- Nausea & vomiting
- Akathisia — a sense of unease and restlessness that presents itself with anxiety
- Lightheadedness
- Constipation
- Emotional instability
- Euphoria or Dysphoria
Common (1–10% incidence)
- Dizziness
- Dyspepsia— indigestion
- Somnolence — which is usually mild and transient and less severe than that seen with most antipsychotics.[6]
- Fatigue
- Restlessness
- Dry mouth
- myoclonic jerks, etc.)
- Orthostatic hypotension
- Musculoskeletal stiffness
- Abdominal discomfort
- Blurred vision
- Cough
- Pain
- Myalgia
- Rash
- Rhinitis
Uncommon (0.1–1% incidence)
- Leukopenia
- Thrombocytopenia
- Bradycardia (low heart rate)
- Palpitations
- Orthostatic hypotension
- Dry eye
- Photophobia
- Diplopia
- Eyelid oedema
- Photopsia
- Diarrhoea
- Gastritis
- Pathological gambling[7]
- Dysphagia
- Gastroesophageal reflux disease
- Swollen tongue
- Oesophagitis
- Hypoaesthesiaoral
- Face oedema
- Gait disturbance
- Chills
- Discomfort
- Feeling abnormal
- Mobility decreased
- Self-mutilation
- Heart rate increased
- Blood glucoseincreased
- Pyrexia
- Blood prolactin increased
- Blood urea increased
- Electrocardiogram QT prolonged
- Blood bilirubin increased
- Hepatic enzyme increased
- Increased appetite
- Nocturia
- Polyuria
- Pollakiuria
- Incontinence
- Urinary retention
- Sexual dysfunction
- Amenorrhoea
- Pruritus
- Photosensitivity reaction
- Urticaria
Rare (<0.1%)
- sweating, reduced consciousness, and sudden change in blood pressure and heart rate)
- Neutropenia[8]
- behavior
- Depression
- Painful and/or sustained erection (Priapism)
- Seizures[9]
- Rhabdomyolysis
- Agranulocytosis
- Cardiopulmonary failure
- Myocardial infarction (heart attack)
- Atrial flutter
- Supraventricular tachycardia
- Ventricular tachycardia
- Atrioventricular block
- Extrasystoles
- Sinus tachycardia
- Atrial fibrillation
- Angina pectoris
- Myocardial ischaemia
- Pancreatitis
- Diabetic ketoacidosis
- Prolonged QT interval (less common than with most other atypical antipsychotic drugs)[6]
- Speech disorder
- Electrolyte abnormalities including hypocalcaemia, etc.
- Hypertension
- Dysphagia
- Oropharyngeal spasm
- Laryngospasm
- Hepatitis
- Jaundice
- Hypersalivation
- Chest pain
- Urinary retention or incontinence
- Alopecia(hair loss)
- Photosensitivity reaction
- Rash
- Xerostomia (when given by injection)
- Tardive dyskinesia (As with all antipsychotic medication, patients using aripiprazole may develop the permanent neurological disorder tardive dyskinesia.)[10][11][12]
- Stroke
- Transient Ischaemic Attack
- Increased body temperature
- Angioedema
- Cardiorespiratory arrest
- Cardiorespiratory failure
Sudden unexplained death has been reported, however the frequency is unknown.[13]
Common in children
- Feeling sleepy
- Headache
- Vomiting
- Fatigue
- Increased appetite
- Insomnia
- Nausea
- Stuffy nose
- Weight gain
- Uncontrolled movement such as restlessness, tremor muscle stiffness[7]
References
- ^ "Product Information for ABILIFY Aripiprazole Tablets & Orally Disintegrating Tablets". TGA eBusiness Services. Bristol-Myers Squibb Australia Pty Ltd. 1 November 2012. Retrieved 22 October 2013.
- ^ "ABILIFY (aripiprazole) tablet ABILIFY (aripiprazole) solution ABILIFY DISCMELT (aripiprazole) tablet, orally disintegrating ABILIFY (aripiprazole) injection, solution [Otsuka America Pharmaceutical, Inc.]". DailyMed. Otsuka America Pharmaceutical, Inc. April 2013. Retrieved 22 October 2013.
- ^ "Abilify Tablets, Orodispersible Tablets, Oral Solution - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Otsuka Pharmaceuticals (UK) Ltd. 20 September 2013. Archived from the original on 4 March 2016. Retrieved 22 October 2013.
- ^ "ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS" (PDF). European Medicines Agency. Otsuka Pharmaceutical Europe Ltd. Retrieved 22 October 2013.
- ^ "Abilify Discmelt, Abilify Maintena (aripiprazole) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 22 October 2013.
- ^ S2CID 32085212.
- ^ a b "ABILIFY (aripiprazole) [package insert]" (PDF). Otsuka Pharmaceutical Co, Ltd. Retrieved 18 October 2012.
- PMID 23334073.
- S2CID 206489666.
- S2CID 11197371.
- S2CID 41849016.
- ^ http://www.medicines.org.uk/EMC/pdfviewer.aspx?isAttachment=true&documentid=16161 [dead link]