Patrick Cramer
Patrick Cramer | |
|---|---|
Karolinska Institutet , Stockholm | |
| Website | www |
Patrick Cramer (born 3 February 1969) is a German chemist, structural biologist, and molecular systems biologist. In 2020, he was honoured to be an international member of the National Academy of Sciences.[1] He became president of the Max Planck Society in June 2023.
Life
Cramer studied chemistry at the
MRC Laboratory for Molecular Biology (LMB) site. In 1995 until 1998 he worked as a PhD student in laboratory of Christoph W. Müller at the European Molecular Biology Laboratory (EMBL) in Grenoble, France. He obtained his PhD in natural sciences (Dr. rer. nat.) from the University of Heidelberg in 1998.[2] From 1999 until 2001 Cramer worked as postdoctoral researcher and fellow of the German Research Foundation (DFG) in the laboratory of the later Nobel Prize laureate Roger D. Kornberg at Stanford University, USA.[3]
In 2001 Patrick Cramer returned to Germany, where he obtained a
German Research Council
(DFG).
On 1 January 2014 Patrick Cramer was appointed Director at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany.[2][5]
From 2016 to 2022 he was a member of the Editorial Board for Cell.[6]
From 22 June 2023, he has served as president of the Max Planck Society.[7]
Achievements
Patrick Cramer conducts basic research as the head of the Department of Molecular Biologyhonorary professor at the University of Göttingen. During his postdoctoral research with Roger Kornberg, Cramer determined the atomic, three-dimensional structure of RNA polymerase II, one of the biggest enzymes in the cell nucleus. This work played a decisive role when the Nobel Prize in chemistry was awarded to Roger Kornberg in 2006 for studies of the molecular basis of eukaryotic transcription.[9]
The laboratory of Patrick Cramer investigates the molecular mechanisms and systemic principles of
cryo-electron microscopy, and biochemical tools. The Cramer laboratory also uses functional genomics and computational biology approaches to study the principles of transcription in living cells.[8]
The group of Patrick Cramer created the first molecular movie of transcription initiation and elongation.[10] Moreover, Patrick Cramer developed methods to analyze fundamental aspects of RNA metabolism in cells by integrating aspects of both molecular and systems biology. His long-term goal is to understand the expression and the regulation of the genome. The laboratory thus pioneers an approach that combines structural and genome-wide methods and may be referred to as molecular systems biology.
In April 2020, Dr Cramer's team at the Max Planck Institute of Biophysical Chemistry created the first "3D structure of the corona polymerase"COVID-19 virus. Their model will allow researchers "to investigate how antiviral drugs such as remdesivir – which blocks the polymerase – work, and to search for new inhibitory substances."[11]
Patrick Cramer also commits himself to the further development of life sciences in Germany and Europe. He was one of the founders of the national cluster of excellence "
Center for Integrated Protein Science (CIPSM)" and initiated the construction of the new research building, the "Munich Research Center for Molecular Biosystems (BioSysM)". In addition, Cramer was one of the members of the scientific and technical advisory board of the Bavarian state government and worked on bioethics within the institute TTN. Patrick Cramer also serves as an organizer of international conferences, and on several scientific committees and advisory boards. Since 2016 Cramer chairs the Council of the European Molecular Biology Laboratory (EMBL).[12]
Publications
Original research articles (selection)
- Schwalb, Björn; Michel, Margaux; Zacher, Benedikt; Frühauf, Katja; Demel, Carina; Tresch, Achim; Gagneur, Julien; Cramer, Patrick (3 June 2016). "TT-seq maps the human transient transcriptome". Science. 352 (6290): 1225–1228. S2CID 8549873.
- Plaschka, C.; Hantsche, M.; Dienemann, C.; Burzinski, C.; Plitzko, J.; Cramer, P. (2016). "Transcription initiation complex structures elucidate DNA opening". Nature. 533 (7603): 353–358. S2CID 4465762.
- Bernecky, Carrie; Herzog, Franz; Baumeister, Wolfgang; Plitzko, Jürgen M.; Cramer, Patrick (2016). "Structure of transcribing mammalian RNA polymerase II". Nature. 529 (7587): 551–554. S2CID 4404463.
- Plaschka, C.; Larivière, L.; Wenzeck, L.; Seizl, M.; Hemann, M.; Tegunov, D.; Petrotchenko, E. V.; Borchers, C. H.; Baumeister, W. (2015). "Architecture of the RNA polymerase II–Mediator core initiation complex". Nature. 518 (7539): 376–380. S2CID 4450934.
- Schulz, Daniel; Schwalb, Bjoern; Kiesel, Anja; Baejen, Carlo; Torkler, Phillipp; Gagneur, Julien; Soeding, Johannes; Cramer, Patrick (21 November 2013). "Transcriptome surveillance by selective termination of noncoding RNA synthesis". Cell. 155 (5): 1075–1087. PMID 24210918.
- Kostrewa, Dirk; Zeller, Mirijam E.; Armache, Karim-Jean; Seizl, Martin; Leike, Kristin; Thomm, Michael; Cramer, Patrick (2009). "RNA polymerase II–TFIIB structure and mechanism of transcription initiation". Nature. 462 (7271): 323–330. S2CID 205218821.
- Bushnell, David A.; Cramer, Patrick; Kornberg, Roger D. (5 February 2002). "Structural basis of transcription: α-Amanitin–RNA polymerase II cocrystal at 2.8 Å resolution". Proceedings of the National Academy of Sciences. 99 (3): 1218–1222. PMID 11805306.
- Cramer, P.; Bushnell, D. A.; Fu, J.; Gnatt, A. L.; Maier-Davis, B.; Thompson, N. E.; Burgess, R. R.; Edwards, A. M.; David, P. R. (28 April 2000). "Architecture of RNA polymerase II and implications for the transcription mechanism". Science. 288 (5466): 640–649. PMID 10784442.
Review articles (selection)
- Plaschka, Clemens; Nozawa, Kayo; Cramer, Patrick (2016). "Mediator Architecture and RNA Polymerase II Interaction". Journal of Molecular Biology. 428 (12): 2569–2574. PMID 26851380.
- Sainsbury, Sarah; Bernecky, Carrie; Cramer, Patrick (2015). "Structural basis of transcription initiation by RNA polymerase II". Nature Reviews Molecular Cell Biology. 16 (3): 129–143. S2CID 32487971.
- Cramer, Patrick (2014). "A Tale of Chromatin and Transcription in 100 Structures". Cell. 159 (5): 985–994. S2CID 8634234.
- Cheung, Alan C.M.; Cramer, Patrick (2012). "A Movie of RNA Polymerase II Transcription". Cell. 149 (7): 1431–1437. S2CID 18405467.
- Cramer, Patrick (2006). "Deciphering the RNA polymerase II structure: a personal perspective". Nature Structural & Molecular Biology. 13 (12): 1042–1044. S2CID 31141435.
Other publications (selection)
- Aufbruch in die molekulare Systembiology. - Essay for the anniversary edition "20 Jahre Laborjournal", Published in Laborjournal on 11 July 2014.
- Entwicklungen in der Biomedizin: Genom-Sequenzierung in Diagnose, Prävention und Therape; Systembiologie und Medizin. In: T. Rendtorff (Hrsg.): Zukunft der biomedizinischen Wissenschaften. Nomos, 2013, ISBN 978-3-8487-0849-9.
- O. Primavesi, P. Cramer, R. Hickel, T. O. Höllmann; W. Schön: Lob der Promotion. Published in Frankfurter Allgemeine Zeitung on 19 July 2013.
- J. Hacker, T. Rendtorff, P. Cramer, M. Hallek, K. Hilpert, C. Kupatt, M. Lohse, A. Müller, U Schroth, F. Voigt, M. Zichy. Biomedizinische Eingriffe am Menschen – Ein Stufenmodell zur ethischen Bewertung von Gen- und Zelltherapie. Water de Gruyter, Berlin. ISBN 978-3-11-021306-5(2009).
Awards and honours (selection)
- 2000 EMBO Young Investigator Award
- 2000 MSC Future Investigator Award
- 2002 GlaxoSmithKlineScience Award
- 2004 10th Eppendorf Award for Young European Researchers
- 2006 Leibniz Prize[13]
- 2008 Bijvoet Medal, Bijvoet Center for Biomolecular Research, Utrecht University[14]
- 2009 Ernst Jung Prize for Medicine[15]
- 2009 Familie-Hansen-Award, Bayer Science & Education Foundation[16]
- 2009 Member, German National Academy of Sciences(Leopoldina)
- 2009 Member, European Molecular Biology Laboratory (EMBL)
- 2010 Advanced Grant of the European Research Council ('TRANSIT')[17]
- 2010 Medal of Honour, Robert Koch Institute
- 2011 Feldberg Foundation Prize[18]
- 2012 Vallee Foundation Visiting Professorship
- 2012 Cross of Merit of the Federal Republic of Germany[19]
- 2012 Paula und Richard von Hertwig Preis
- 2015 Arthur Burkhardt Preis[20]
- 2015 Guest Professor, Karolinska Institutet, Stockholm, Sweden[21]
- 2016 Advanced Grant of the European Research Council ('TRANSREGULON')[22]
- 2016 Centenary Award of the British Biochemical Society[23]
- 2017 Elected Member, Academia Europaea
- 2017 Honorary Professor, Georg August University of Göttingen
- 2017 Weigle Lectureship, University of Geneva
- 2018 Inaugural George William Jourdian Lectureship, University of Michigan
- 2019 Ernst Schering Prize
- 2020 Otto Warburg Medal
- 2021 Louis-Jeantet Prize for Medicine[24]
- 2023 Shaw Prize in Life Sciences[25]
References
- ^ "2020 NAS Election". www.nasonline.org.
- ^ a b c d "Website of the Max Planck Institute for Biophysical Chemistry, CV" (PDF).
- ^ "Website of the Kornberg Laboratory: List of current and past lab members". Retrieved 23 May 2017.
- ^ "History of the Gene Center of the University of Munich LMU". Archived from the original on 1 March 2012. Retrieved 23 May 2017.
- ^ "Press release by the Max Planck Institute for Biophysical Chemistry: Patrick Cramer appointed Director". Max Planck Institute for Biophysical Chemistry. 2 January 2014. Retrieved 23 May 2017.
- ^ "Editorial Board: Cell".
- ^ "Patrick Cramer wird ab Juni 2023 neuer Präsident der Max-Planck-Gesellschaft". www.mpg.de (in German). Retrieved 11 July 2022.
- ^ a b "Website of the Cramer Laboratory at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany". Retrieved 23 May 2017.
- ^ "Advanced information on the Nobel Prize in Chemistry 2006" (PDF). Retrieved 23 May 2017.
- PMID 22726432.
- ^ a b "Researchers Solve Structure of SARS-CoV-2 Viral Copy Machine". from Technology Networks. Retrieved 29 April 2020.
- ^ "Website of the EMBL Council". Retrieved 23 May 2017.
- ^ "Press release by the German Research Foundation (DFG) on the Leibniz Price 2006". Retrieved 23 May 2017.
- ^ "Bijvoet Medal". Bijvoet Center for Biomolecular Research. Archived from the original on 12 September 2017. Retrieved 12 September 2017.
- ^ "List of laureates of the Ernst Jung Prize for Medicine". Archived from the original on 19 September 2016. Retrieved 23 May 2017.
- ^ "Website of the Bayer Foundation on the Hansen Family Award". Retrieved 23 May 2017.
- ^ "Press release by the University of Munich: Patrick Cramer receives ERC Advanced Grant". Retrieved 23 May 2017.
- ^ "Website of the Feldberg Foundation Prize". Retrieved 23 May 2017.
- ^ "Press release of the University of Munich: Cross of Merit for Patrick Cramer". Retrieved 23 May 2017.
- ^ "Website of the Arhur Burkhardt Foundation". Retrieved 23 May 2017.
- ^ "Website of the Cramer Laboratory at the Karolinska Institutet Stockholm, Sweden". Retrieved 23 May 2017.
- ^ "Press release by the Max Planck Institute for Biophysical Chemistry, Göttingen, Germany: Advanced Grant of the ERC for Patrick Cramer". Retrieved 23 May 2017.
- ^ "Biochemical Society – The Centenary Award". Retrieved 23 May 2017.
- ^ "Patrick Cramer erhält den Louis-Jeantet-Preis für Medizin 2021". Max-Planck-Gesellschaft (in German). 31 March 2021. Retrieved 30 April 2021.
- ^ Shaw Prize 2023
External links
- Patrick Cramer at the Max Planck Institute for Biophysical Chemistry in Göttingen
- List of publications
- Cramer at the Gene Center Munich
- (in German) Porträt at the Deutschen Forschungsgesellschaft
| International | |
|---|---|
| National | |
| Academics | |
| People | |
