Primary peritoneal carcinoma

Source: Wikipedia, the free encyclopedia.
Primary peritoneal carcinoma
serous carcinoma, which may arise from the peritoneal lining
SpecialtyOncology Edit this on Wikidata

Primary peritoneal cancer or carcinoma is also known as serous surface papillary carcinoma, primary peritoneal carcinoma, extra-ovarian serous carcinoma, primary serous papillary carcinoma, and psammomacarcinoma. It was historically classified under "

carcinoma of unknown primary" (CUP). Primary peritoneal cancer (PPC, or PPCa)[1] is a cancer of the cells lining the peritoneum, or abdominal cavity. It usually affects women and is diagnosed after the age of 60; it very rarely affects men.[2]

serous carcinomas, which include ovarian serous carcinoma, uterine serous carcinoma, fallopian tube serous carcinoma, cervical serous carcinoma, and primary peritoneal serous carcinoma really represent one entity.[3]

Genetic causes

Although the precise causes are not known, a link with certain variants of BRCA1/2 has been described.[4] Furthermore, women with BRCA1/2 mutation have a 5% risk of developing primary peritoneal cancer even after prophylactic oophorectomy.

Primary peritoneal carcinoma shows similar rates of

WT1
) as ovarian cancer and can also show an increased expression of HER-2/neu.

An association with vascular endothelial growth factor has been observed.[5]

Signs & Symptoms

Prognosis

Prognosis and treatment is the same as for the most common type of ovarian cancer, which is

epithelial ovarian cancer.[6][7]

The median survival of primary peritoneal carcinomas is usually shorter by 2–6 months time when compared with serous ovarian cancer. Studies show median survival varies between 11.3 and 17.8 months. One study reported 19–40 month median survival (95% CI) with a five-year survival of 26.5%.[medical citation needed]

Elevated albumin levels have been associated with a more favorable prognosis.[8]

References

  1. S2CID 2907689
    .
  2. ^ Type, Cancer (21 February 2022). "Primary peritoneal cancer". Cancer Research UK.
  3. PMID 19038766
    .
  4. ^ "Gynecologic Cancer Treatment—Primary Peritoneal Cancer—Dana-Farber Cancer Institute". Archived from the original on 2008-04-29. Retrieved 2008-05-07.
  5. PMID 18024863
    .
  6. ^ "New Drug Combination for Ovarian and Primary Peritoneal Cancers - National Cancer Institute". Archived from the original on 2010-12-24. Retrieved 2008-05-07.
  7. ^ Peritoneal Cancer at eMedicine
  8. PMID 16876237
    .
Retrieved from "https://en.wikipedia.org/w/index.php?title=Primary_peritoneal_carcinoma&oldid=1219003037"