Linitis plastica
| Linitis plastica | |
|---|---|
| Other names | Leather bottle stomach |
 | |
| Endoscopic image of linitis plastica, where the entire stomach is invaded with stomach cancer, leading to a leather bottle like appearance | |
| Specialty | Oncology  |
Linitis plastica (sometimes referred to as leather bottle stomach) is a morphological variant of diffuse stomach cancer in which the stomach wall becomes thick and rigid.[1]
Linitis plastica is a type of
E-cadherin. The hereditary form of this cancer, hereditary diffuse gastric cancer, accounts for only 1–3% of gastric adenocarcinomas. Somatic mutations in this gene are found in about 50% of diffuse-type gastric carcinomas.[2]
Signs and symptoms
Diffuse stomach cancer is characterized by the presence of poorly differentiated tumor cells. Under a microscope, these appear as
signet ring cells
, meaning that mucin droplets are visible that displace the nucleus to one side.
Symptoms of linitis plastica do not usually present until the disease is in an advanced stage, making early diagnosis difficult. Symptoms are similar to those of stomach cancer including: difficulty swallowing, weight loss, indigestion, and vomiting.[3]
History
The condition was defined by William Brinton in 1859.[4]
Notable cases
Napoleon Bonaparte and many members of his family are thought to have died from this type of cancer, although it is believed by others that he may have died from arsenic poisoning.[5]
References
- ^ PMID 23984032.)
{{cite journal}}: CS1 maint: multiple names: authors list (link - ^ a b Robbins Basic Pathology, 8th Edition
- ^ "Linitis plastica of the stomach | Cancer Research UK".
- PMID 28679451.
- PMID 10209666.
External links
Wikimedia Commons has media related to Linitis plastica.
- "Carcinoma of the Stomach." at patient.info