Rodolfo Llinás

Rodolfo Llinás
Rodolfo Llinás Riascos
Sir John Eccles

Neuropsychology
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Rodolfo Llinás Riascos (born 16 December 1934) is a Colombian and American

Llinás was born in Bogotá, Colombia. He is the son of Jorge Enrique Llinás (a surgeon of Spanish descent, whose family arrived in Colombia at the end of the 19th century)^[2] and Bertha Riascos. He was motivated to study the brain by watching his grandfather Pablo Llinás Olarte working as a neuropsychiatrist. Llinás describes himself as a logical positivist.^[3]

Education and early research

Llinás went to the

By graduation in Australia, he was very interested in the biological basis of the mind. During this time he met his future wife who was studying philosophy. His two sons, Drs. Rafael and Alexander Llinas, are also physicians. His wife, Gillian Llinas (née Kimber) is an Australian philosopher of mind. Llinás was a scientific advisor during the establishment of an interactive science museum located in Bogotá, Colombia called Maloka Museum. In 2018, Llinás donated a T-Rex skeleton to the museum and helped to design a model of the nervous system for the dinosaur fossils.^[6][7]

Work

He has studied the electrophysiology of single neurons in the

Llinás has occupied a number of positions.^[citation needed]

• Research fellow, Massachusetts General Hosp.-Harvard University, 1960–61
• National Institutes of Health research fellow in physiology, University of Minnesota, Minneapolis, 1961–63
• Associate professor, University Minnesota, Minneapolis, 1965–66
• Associate member, American Medical Association Institute Biomed. Research, Chicago, 1966–68
• Member, American Medical Association Institute Biomed. Research, Chicago, 1970
• Head neurobiology unit, American Medical Association Institute Biomed. Research, Chicago, 1967–70
• Associate professor neurology and psychiatry, Northwestern University, 1967–71
• Guest professor physiology, Wayne State University, 1967–74
• Professorial lecturer pharmacology, University Ill.-Chgo., 1967–68
• Clinical professor, University Ill.-Chgo., 1968–72
• Professor physiology, head neurobiology div., University of Iowa, 1970–76
• Prof., chairman physiology and biophysics, New York University, New York City, 1976—2011
• Thomas and Suzanne Murphy professor neuroscience., New York University, 1985—
• University Professor, Department of Neuroscience and Physiology., New York University, 2011—

Contributions

Llinás is known for his many contributions to neuroscience, however, his most important contributions are the following:

• Discovery of dendritic inhibition in central neurons (at the mammalian
  motoneuron).^[9][10]
• The functional organization of the
  cerebellar cortex neuronal circuits.^[11]
• Defining cerebellar function from an evolutionary perspective.[12]
• First description of electrical coupling in the mammalian CNS (
  mesencephalic trigeminal nucleus).^[13]
• First determination of presynaptic calcium current, under voltage clamp, at the squid giant synapse.^[14][15]
• Discovery that vertebrate neurons (cerebellar Purkinje cell) can generate calcium-dependent spikes.^[16][17]
• Proposal and Organization of NASA Neurolab Project that flew on April 17, 1998, Space Shuttle Columbia.^[18]
• Discovery of the P-type calcium channel in the Purkinje cells.^[16]
• Discovery of
  inferior olive and thalamus neurons.^[19][20]
• A tensor network model of the transformation of sensory space-time coordinates into motor coordinates by the cerebellum.^[21]
• Asserting the law of no interchangeability of neurons, which it is known as
  Llinás' law.^[22]
• Direct demonstration of calcium concentration microdomains at the presynaptic active zone.^[23]
• Utilization of magnetoencephalography in clinical research.^[24]
• Discovery of subthreshold membrane potential oscillations in the inferior olive, thalamus and entorhinal cortex.^[25][26]
• The discovery of Thalamocortical dysrhythmia.^[8]
• Artificial olivo-cerebellar motor control system as part of the project BAUV (Undersea Vehicle) of the
  US Navy developed by P. Bandyopadhyay.^[27][28]

• Universidad de Salamanca
  (Spain) (1985)
• Universitat Autonoma de Barcelona
  (Spain) (1993)
• National University of Colombia (1994)
• Universidad Complutense
  , Madrid, Spain (1997)
• Los Andes University
  (Colombia), Bogotá, Colombia, (1998)
• Toyama University
  , Toyama, Japan (2005)
• University of Pavia, Pavia, Italy (2006)

Dr. Llinás has received the following awards:

• UNESCO Albert Einstein medal
  (1991)
• Order of Boyaca Awarded President of Colombia
  for exceptional service to Colombia (1992)
• Bernard Katz Award Biohysical Society, Washington USA (2012)[3]
• Gold Medal of CSIC [es], Spanish National Research Council, Madrid, Spain (2012)[4]
• Cajal Diploma given by Queen Sofia of Spain Madrid, Spain (2013)^{[citation needed]}
• Ragnar Granit Lecture and Award, Nobel Institute, Stockholm, Sweden (2013)
• Castilla del Pino Lecture and Award Cordoba, Spain (2015)[5]
• Nansen Neuroscience Lecture and award Norwegian Academy of Science, Oslo, Norway (2016)[6]
• Scholar of the Year Australian National University, Canberra, Australia (2016)[7]
• Ralph W. Gerard Prize in Neuroscience Society for Neuroscience, (2018) [8]

He was the chairman of NASA/Neurolab Science Working Group, in 2011 received University Professor Distinction from New York University [9] and in 2013, the NYU Neuroscience Institute created the Annual Rodolfo Llinás Lecture Series in recognition of his contributions to the field of neuroscience.^[30]

Filmography

• Llinas, el cerebro y el universo. Documentary film, by Gonzalo Argandoña, Cabala Producción Audiovisual, (2018) RTVCplay [10]

Selected bibliography

Llinás is the author of more than 20 book chapters and has edited several books on neuroscience.

Books

• Hubbard, J.I., Llinás, R. and Quastel, D.M.J. Electrophysiological Analysis of Synaptic Transmission. London: Edward Arnold Publishers 1969.
• Llinás, R. Editor. Neurobiology of Cerebellar Evolution and Development. (Chicago: Am. Med. Association, 1969)
• Precht, W., Llinás, R. (eds.): Frog Neurobiology: a handbook. (Berlin: Springer-Verlag, 1976). link.springer.com/10.1007/978-3-642-66316-1
  ISBN 978-3-642-66318-5
• Steriade, M., Jones, E., y Llinás, R (Eds.): Thalamic Oscillations and Signaling. The Neurosciences Institute Publications Series. (John Wiley & Sons, 1990).
  ISBN 0-471-51508-6
• Llinás, R. y Sotelo, C (eds.): The Cerebellum Revisited. (Nueva York: Springer-Verlag, 1992). link.springer.com/10.1007/978-1-4612-2840-0
  ISBN 978-1-4612-7691-3
• Buzsaki, G., Llinas, R., Singer, W., Berthoz, A., Christen, Y. (eds.): Temporal Coding in the Brain. (Nueva York: Springer-Verlag, 1994). link.springer.com/10.1007/978-3-642-85148-3
  ISBN 978-3-642-85150-6
• Latorre, R., López-Barneo, J., Bezanilla, F., Llinás, R. (Eds) Biofísica y fisiología celular. (Universidad de Sevilla, España, 1996).
  ISBN 84-472-0339-5
• Llinás, Rodolfo R. and Churchland, Patricia S. Mind-Brain Continuum: Sensory Processes The MIT Press (September 9, 1996)
  ISBN 0-262-12198-0
• Llinás, Rodolfo R. The Squid Giant Synapse : A Model for Chemical Transmission Oxford University Press, USA (December 15, 1999)
  ISBN 0-19-511652-6
• Llinás, Rodolfo. El reto: Educación, Ciencia y Tecnología. Tercer Mundo Editores, (2000)
  ISBN 978-958-601-887-6
• Llinás, R.
  ISBN 0-262-62163-0

Book chapters

• Llinas R, Rivary U. Perception as an oneiric-like state modulated by the senses. Chapter 6. In: Koch C. Large-scale neuronal theories of the brain. Bradford Book. (1994).
  ISBN 9780262111836
• Llinas RR., Walton KD. Cerebellum. Chapter 7. In: Shepherd GM. The synaptic organization of the brain. 4th Ed. New York: Oxford University Press. (1998)
  ISBN 0195118243
• Llinas RR., Walton KD., Lang EJ. Cerebellum. Chapter 7. In: Shepherd GM. The synaptic organization of the brain. 5th Ed. Oxford University Press. (2004)
  ISBN 0195159551
• Llinas, R. R. Neuroscientific basis of consciousness and dreaming. Chapter 3.6. In: Kaplan and Sadock's Comprehensive textbook of psychiatry. Philadelphia: Lippincott Williams & Wilkins. 8th ed. (2005).
• Llinás, R. Electrophysiology of the Cerebellar Networks. Comprehensive Physiology (2011). Supplement 2. Handbook of Physiology, The Nervous System, Motor Control.
  ISBN 9780470650714
• Llinas RR., Walton K. Central pain: a thalamic deafferentation generating thalamocortical dysrhythmia. Chapter 4. In: Saab CY. Chronic pain and brain abnormalities. Academic Press-Elsevier (2014).
  ISBN 9780123983893
• Llinas, RR. Oscillation in the inferior olive neurons: Functional implication. Chapter 39. pp. 293–298. In: Essentials of Cerebellum and Cerebellar Disorders: A Primer for Graduate Students. Springer (2016)
  ISBN 978-3-319-24551-5
• Llinas, R. R. Consciousness and Dreaming from a Pathophysiological Perspective: The Thalamocortical Dysrhythmia Syndrome. Chapter 3.5. In: Kaplan and Sadock's Comprehensive textbook of psychiatry. Philadelphia: Lippincott Williams & Wilkins. 10th ed. (2017).
  ISBN 978-1-4511-0047-1

Selected review articles

• Llinás RR (December 1988). "The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function". Science. 242 (4886): 1654–64.
  PMID 3059497
  .
• Llinás RR, Sugimori M, Cherksey B (1989). "Voltage-dependent calcium conductance in mammalian neurons. The P channel". Ann N Y Acad Sci. 560: 103–11.
  S2CID 84107834.{{cite journal}}: CS1 maint: multiple names: authors list (link
  )
• Llinás RR (1991). "Depolarization release coupling: an overview". Ann N Y Acad Sci. 635 (1): 3–17.
  S2CID 30849546
  .
• Llinás RR, Paré D (1991). "Of dreaming and wakefulness". Neuroscience. 44 (3): 521–35.
  S2CID 32125577
  .
• Llinás R, Ribary U (Apr 2001). "Consciousness and the brain. The thalamocortical dialogue in health and disease". Ann N Y Acad Sci. 929: 166–75.
  S2CID 146564098
  .
• Llinás Rodolfo R., Steriade Mircea (2006). "Bursting of thalamic neurons and states of vigilance. Invited Review". J. Neurophysiol. 95 (6): 3297–3308.
  PMID 16554502
  .
• Roy S, Llinás R (2007). "Dynamic geometry, brain function modeling, and consciousness". Models of Brain and Mind - Physical, Computational and Psychological Approaches. Progress in Brain Research. Vol. 168. pp. 133–44.
  PMID 18166391. {{cite book}}: |journal= ignored (help
  )
• Llinás RR (2011). "Cerebellar motor learning versus cerebellar motor timing: the climbing fibre story". J Physiol. 589 (14): 3423–32.
  PMID 21486816
  .
• Buzsáki G, Llinás R (2017). "Space and time in the brain". Science. 358 (6362): 482–485.
  PMID 29074768
  .

References

1. ^ NYU Health Sciences Library: Faculty Bibliography. Retrieved June 14, 2021
2. ^ ""La pregunta difícil": La vida y obra de Rodolfo Llinás". elespectador.com (in Spanish). 25 November 2017. Retrieved 16 May 2021.
3. ^ P. (2016). Rodolfo R. Llinas - Can Science Talk God? Retrieved August 26, 2016, from https://www.closertotruth.com/series/can-science-talk-god
4. ^
   ISBN 978-0-12-370514-3
   .
5. ISBN 9789585425408
   .
6. ^ Tiempo, Casa Editorial El (2018-07-24). "Maloka se reinventa y estrena atracción: un tiranosaurio rex". El Tiempo (in Spanish). Retrieved 2019-05-22.
7. ^ EL TIEMPO (2018-07-26), Rodolfo Llinás regaló un T Rex a Maloka | EL TIEMPO, retrieved 2019-05-22
8. ^
   PMID 10611366
   .
9. PMID 14194959
   .
10. PMID 14283063
    .
11. ISBN 978-0-19-515955-4
    .
12. PMID 5397400
    .
13. PMID 5545184
    .
14. PMID 183215
    .
15. PMID 6256531
    .
16. ^
    PMID 7441552
    .
17. PMID 7441553
    .
18. ISBN 978-0-9725339-0-4
    .
19. PMID 6273544
    .
20. PMID 7310722
    .
21. PMID 18166391
    .
22. ^ Llinás, Rodolfo (1990). «Intrinsic Electrical Properties of Mammalian Neurons and CNS Function». Fidia Research Foundation Neuroscience Award Lectures, 1988-1989 (Raven Press) 4: p. 175.
23. PMID 1350109
    .
24. PMID 8916327
    .
25. PMID 3795074
    .
26. S2CID 1892764
    .
27. S2CID 21127267
    .
28. S2CID 133526257
    .
29. ^ "APS Member History". search.amphilsoc.org. Retrieved 2021-12-10.
30. ^ "Neuroscience Institute Events".

External links

Wikimedia Commons has media related to Rodolfo Llinás.

• NYU Neurophysiology website about Rodolfo Llinás
• NYU Medicine faculty website about Rodolfo Llinás
• "List of Articles on Google Scholar". Google Scholar. 2016. Retrieved 2 June 2016.

Newspaper articles

• Estrella de la sabiduría en la Universidad Nacional Tribute at National University of Colombia
• Enter the "I" of the Vortex The Science Network interview with Rodolfo Llinás
• In a Host of Ailments, Seeing a Brain Out of Rhythm The New York Times December 8, 2008
• New Way Of Looking At Diseases Of the Brain The New York Times October 26, 1999
• Listening to the Conversation of Neurons The New York Times May 27, 1997
• New York Times announcement of election to the [National Academy of Sciences]