VEGF receptor
VEGF receptor | |
---|---|
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | |
Identifiers | |
Symbol | VEGF |
InterPro | IPR009135 |
Membranome | 1335 |
Identifiers | |||||||
---|---|---|---|---|---|---|---|
Symbol | Chr. 13 q12 | ||||||
|
Chr. 4 q11-q12 | |||||||
---|---|---|---|---|---|---|---|
|
Chr. 5 q34-q35 | |||||||
---|---|---|---|---|---|---|---|
|
VEGF receptors (VEGFRs) are
Inhibitors of VEGFR are used in the treatment of cancer.
VEGF
Receptor biology
All members of the VEGF family stimulate cellular responses by binding to
VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF.[1] The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 is to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). In fact, an alternatively spliced form of VEGFR-1 (sFlt1) is not a membrane bound protein but is secreted and functions primarily as a decoy.[6] A third receptor has been discovered (VEGFR-3), however, VEGF-A is not a ligand for this receptor. VEGFR-3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D.
In addition to binding to VEGFRs, TACO VEGF binds to receptor complexes consisting of both neuropilins and VEGFRs. This receptor complex has increased VEGF signalling activity in endothelial cells (blood vessels).[7][8] Neuropilins (NRP) are pleiotropic receptors and therefore other molecules may interfere with the signalling of the NRP/VEGFR receptor complexes. For example, Class 3 semaphorins compete with VEGF165 for NRP binding and could therefore regulate VEGF-mediated angiogenesis.[9]
References
External links
- VEGF+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Proteopedia Vascular_Endothelial_Growth_Factor_Receptor - the Vascular Endothelial Growth Factor Receptor Structure in Interactive 3D