TGF beta receptor 2
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 3: 30.61 – 30.69 Mb | Chr 9: 115.91 – 116 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Transforming growth factor, beta receptor II (70/80kDa) is a TGF beta receptor. TGFBR2 is its human gene.
It is a tumor suppressor gene.[5]
Function
This gene encodes a member of the
Osler–Weber–Rendu syndrome, and the development of various types of tumors. At least 73 disease-causing mutations in this gene have been discovered.[6] Alternatively spliced transcript variants encoding different isoforms have been characterized.[7]
Interactions
TGF beta receptor 2 has been shown to
interact
with:
Domain architecture
| Transforming growth factor beta receptor 2 ectodomain | |||||||||
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 crystal structure of human tgf-beta type ii receptor ligand binding domain | |||||||||
| Identifiers | |||||||||
| Symbol | ecTbetaR2 | ||||||||
| Pfam | PF08917 | ||||||||
| InterPro | IPR015013 | ||||||||
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TGF beta receptor 2 consists of a
beta-sheets (beta1-beta4, beta3-beta9).[18]
See also
- TGF beta receptors
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163513 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032440 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "TGFBR2 - transforming growth factor, beta receptor II (70/80kDa) - Genetics Home Reference". Archived from the original on 2011-08-10. Retrieved 2008-09-07.
- PMID 31819097.
- ^ "Entrez Gene: TGFBR2 transforming growth factor, beta receptor II (70/80kDa)".
- PMID 12429842.
- PMID 9926943.
- ^ PMID 9872992.
- PMID 12015308.
- PMID 18591668.
- PMID 9856985.
- PMID 10757800.
- PMID 7890683.
- PMID 11102446.
- PMID 12729750.
- ^ S2CID 13322593.
- PMID 11157754.
External links
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