60S ribosomal protein L22
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60S ribosomal protein L22 is a protein that in humans is encoded by the RPL22 gene on Chromosome 1.[5][6]
Function
polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2.[6]
Insects
The gene may play a role in Insect toxicity resistance. In culex mosquitos, it was one of several ribosomal proteins which were overexpressed in strains resistant to the insecticide deltamethrin.[7] More focused analysis revealed that resistant mosquitoes expressed RPL22 at a level more than 2.5x higher than susceptible strains; however, the same study found that over-expression of RPL22 in transfected cells caused a down-regulation of a different deltamethrin-resistance gene (CYP6A1) and made these cells overall less resistant to the insecticide.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000116251 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028936 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8395054.
- ^ a b "Entrez Gene: RPL22 ribosomal protein L22".
- .
- S2CID 5058277.
Further reading
- Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochemistry and Cell Biology. 73 (11–12): 933–47. PMID 8722009.
- Toczyski DP, Steitz JA (February 1991). "EAP, a highly conserved cellular protein associated with Epstein-Barr virus small RNAs (EBERs)". The EMBO Journal. 10 (2): 459–66. PMID 1846807.
- Fujita Y, Okamoto T, Noshiro M, McKeehan WL, Crabb JW, Whitney RG, Kato Y, Sato JD, Takada K (March 1994). "A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22". Biochemical and Biophysical Research Communications. 199 (2): 706–13. PMID 8135813.
- Sanger Centre, The; Washington University Genome Sequencing Cente, The (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. PMID 9847074.
- Le S, Sternglanz R, Greider CW (March 2000). "Identification of two RNA-binding proteins associated with human telomerase RNA". Molecular Biology of the Cell. 11 (3): 999–1010. PMID 10712515.
- Shu-Nu C, Lin CH, Lin A (October 2000). "An acidic amino acid cluster regulates the nucleolar localization and ribosome assembly of human ribosomal protein L22". FEBS Letters. 484 (1): 22–8. S2CID 17840004.
- Uechi T, Tanaka T, Kenmochi N (March 2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. PMID 11401437.
- Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. S2CID 14132033.
- Yoshihama M, Uechi T, Asakawa S, Kawasaki K, Kato S, Higa S, Maeda N, Minoshima S, Tanaka T, Shimizu N, Kenmochi N (March 2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Research. 12 (3): 379–90. PMID 11875025.
- Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. S2CID 4344740.
- Chen KC, Chiang HS, Fang CL (2005). "EBER expression of pure urinary bladder lymphoepithelioma-like carcinoma in two unique Asian patients". Urologia Internationalis. 74 (3): 280–2. S2CID 24326120.
- Fok V, Mitton-Fry RM, Grech A, Steitz JA (May 2006). "Multiple domains of EBER 1, an Epstein-Barr virus noncoding RNA, recruit human ribosomal protein L22". RNA. 12 (5): 872–82. PMID 16556938.
- Nakao K, Mochiki M, Nibu K, Sugasawa M, Uozaki H (April 2006). "Analysis of prognostic factors of nasopharyngeal carcinoma: impact of in situ hybridization for Epstein-Barr virus encoded small RNA 1". Otolaryngology–Head and Neck Surgery. 134 (4): 639–45. S2CID 29788079.
External links
- Overview of all the structural information available in the PDB for UniProt: P35268 (60S ribosomal protein L22) at the PDBe-KB.
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