EIF-2 kinase
Source: Wikipedia, the free encyclopedia.
Protein serine/threonine kinase that is induced by interferon
eIF-2-alpha kinase is a kinase enzyme that phosphorylates eIF2α. There are four forms in mammals: [2]
- heme-regulated inhibitor kinase (HRI)
- EIF2AK2: the double-stranded RNA-dependent kinase (protein kinase R, PKR)
- EIF2AK3: also known as "PKR-like endoplasmic reticulum kinase" (PEK/PERK)
- EIF2AK4: also known as GCN2
These are all responsible for the phosphorylation of the alpha subunit of eIF-2 at serine 51, one of the best-characterized mechanisms for down-regulating protein synthesis in eukaryotes as a part of cellular stress response.[3]
References
- PMID 11042214.
- ^ "Gene group | HUGO Gene Nomenclature Committee". www.genenames.org.
- PMID 10504407.
| Proteins |
| ||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Other concepts |
| ||||||||||||||||||||||||||||||||
| ||
|---|---|---|
| Pyruvate dehydrogenase kinase (EC 2.7.11.2) | ||
| Dephospho-(reductase kinase) kinase (EC 2.7.11.3) | ||
| 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4) | ||
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5) | ||
| (tyrosine 3-monooxygenase) kinase (EC 2.7.11.6) | ||
| Myosin-heavy-chain kinase (EC 2.7.11.7) |
| |
| Fas-activated serine/threonine kinase (EC 2.7.11.8) | ||
| Goodpasture-antigen-binding protein kinase (EC 2.7.11.9) |
| |
| IκB kinase (EC 2.7.11.10) | ||
| cAMP-dependent protein kinase (EC 2.7.11.11) | ||
| cGMP-dependent protein kinase (EC 2.7.11.12) | ||
| Protein kinase C (EC 2.7.11.13) | ||
| Rhodopsin kinase (EC 2.7.11.14) | ||
Beta adrenergic receptor kinase (EC 2.7.11.15) |
| |
| G-protein coupled receptor kinases (EC 2.7.11.16) | ||
Ca2+/calmodulin-dependent (EC 2.7.11.17) |
| |
| Myosin light-chain kinase (EC 2.7.11.18) | ||
| Phosphorylase kinase (EC 2.7.11.19) | ||
| Elongation factor 2 kinase (EC 2.7.11.20) | ||
| Polo kinase (EC 2.7.11.21) | ||
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30) | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||||||||||
Dual-specificity kinases (EC 2.7.12) | |||
|---|---|---|---|
| |||
| Activity | |
|---|---|
| Regulation | |
| Classification | |
| Kinetics | |
| Types |
|
