Amorpha-4,11-diene 12-monooxygenase
Amorpha-4,11-diene 12-monooxygenase | |||||||||
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Identifiers | |||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Amorpha-4,11-diene 12-monooxygenase (EC 1.14.13.158, CYP71AV1) is an enzyme with systematic name amorpha-4,11-diene,NADPH:oxygen oxidoreductase (12-hydroxylating).[1] This enzyme catalyses the following chemical reaction
- amorpha-4,11-diene + 3 O2 + 3 NADPH + 3 H+ artemisinate + 3 NADP+ + 4 H2O (overall reaction)
- (1a) amorpha-4,11-diene + O2 + NADPH + H+ artemisinic alcohol + NADP+ + H2O
- (1b) artemisinic alcohol + O2 + NADPH + H+ artemisinic aldehyde + NADP+ + 2 H2O
- (1c) artemisinic aldehyde + O2 + NADPH + H+ artemisinate + NADP+ + H2O
Amorpha-4,11-diene 12-monooxygenase is a heme-thiolate protein (P-450)
References
- PMID 16458889.
External links
- Amorpha-4,11-diene+12-monooxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)