Camphor 5-monooxygenase
camphor 5-monooxygenase | |||||||||
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ExPASy NiceZyme view | | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In
- (+)-camphor + putidaredoxin + O2 (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O
The 3
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor. The systematic name of this enzyme class is (+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (5-hydroxylating). Other names in common use include camphor 5-exo-methylene hydroxylase, 2-bornanone 5-exo-hydroxylase, bornanone 5-exo-hydroxylase, camphor 5-exo-hydroxylase, camphor 5-exohydroxylase, camphor hydroxylase, d-camphor monooxygenase, methylene hydroxylase, methylene monooxygenase, D-camphor-exo-hydroxylase, and camphor methylene hydroxylase. It employs one cofactor, heme.
Structural studies
As of late 2007, 58
Examples
Camphor 5-monooxygenase | |||||||
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Identifiers | |||||||
Organism | |||||||
Symbol | camC | ||||||
Alt. symbols | cyp101 | ||||||
UniProt | P00183 | ||||||
Other data | |||||||
EC number | 1.14.15.1 | ||||||
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Putidaredoxin | |||||||
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Identifiers | |||||||
Organism | |||||||
Symbol | camB | ||||||
Alt. symbols | PDX | ||||||
UniProt | P00259 | ||||||
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Putidaredoxin reductase CamA | |||||||
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Identifiers | |||||||
Organism | |||||||
Symbol | camA | ||||||
Alt. symbols | Pdr | ||||||
UniProt | P16640 | ||||||
Other data | |||||||
EC number | 1.18.1.5 | ||||||
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Cytochrome P450 camphor 5-monooxygenase is a bacterial enzyme originally from Pseudomonas putida, which catalyzes a critical step in the metabolism of camphor. In 1987, Cytochrome P450cam was the first cytochrome P450 three-dimensional protein structure solved by X-ray crystallography.[1]
It is a
References
Further reading