CYP2S1
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 19: 41.19 – 41.21 Mb | Chr 7: 25.5 – 25.52 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Cytochrome P450 2S1 is a protein that in humans is encoded by the CYP2S1 gene.[5][6] The gene is located in chromosome 19q13.2 within a cluster including other CYP2 family members such as CYP2A6, CYP2A13, CYP2B6, and CYP2F1.[7]
Expression
CYP2S1 is highly expressed in epithelial tissues of the respiratory, gastrointestinal, urinary tracts, and skin and in
Function
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens although its specific function(s) in humans has not been clearly determined.
CYP2S1 has been suggested to be involved in the growth and/or spread of certain tumors of
CYP2S1 has recently been assigned
Vernolic and coronaric acids are potentially toxic, causing
CYP2S1 has also been found to metabolize Prostaglandin G2 and Prostaglandin H2 to the biologically active product, 12-Hydroxyheptadecatrienoic acid (i.e. 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid, also termed 12-HHT).[12]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000167600 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040703 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 11181079.
- ^ a b "Entrez Gene: CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1".
- ^ PMID 16054184.
- PMID 26743604.
- S2CID 3481077.
- S2CID 23287346.
- S2CID 37734580.
- ^ S2CID 9158244.
- ^ PMID 25093613.
External links
- Human CYP2S1 genome location and CYP2S1 gene details page in the UCSC Genome Browser.
Further reading
- Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
- Smith G, Wolf CR, Deeni YY, Dawe RS, Evans AT, Comrie MM, Ferguson J, Ibbotson SH (April 2003). "Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases". Lancet. 361 (9366): 1336–43. S2CID 42519228.
- Saito S, Iida A, Sekine A, Kawauchi S, Higuchi S, Ogawa C, Nakamura Y (2003). "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population". Journal of Human Genetics. 48 (5): 249–70. PMID 12721789.
- Rivera SP, Wang F, Saarikoski ST, Taylor RT, Chapman B, Zhang R, Hankinson O (April 2007). "A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P4502S1 by both dioxin and hypoxia". The Journal of Biological Chemistry. 282 (15): 10881–93. PMID 17277313.
- Marek CJ, Tucker SJ, Koruth M, Wallace K, Wright MC (February 2007). "Expression of CYP2S1 in human hepatic stellate cells". FEBS Letters. 581 (4): 781–6. S2CID 24479485.
- Hanzawa Y, Sasaki T, Hiratsuka M, Ishikawa M, Mizugaki M (April 2007). "Three novel single nucleotide polymorphisms (SNPs) of CYP2S1 gene in Japanese individuals". Drug Metabolism and Pharmacokinetics. 22 (2): 136–40. PMID 17495422.
- Jang YJ, Cha EY, Kim WY, Park SW, Shon JH, Lee SS, Shin JG (June 2007). "CYP2S1 gene polymorphisms in a Korean population". Therapeutic Drug Monitoring. 29 (3): 292–8. S2CID 27240042.