Autophagin
Autophagin-1 (Atg4/Apg4) is a unique
carboxyl terminus of Atg8/Apg8/Aut7, a reaction essential for its lipidation during autophagy.[1] Human Atg4 homologues cleave the carboxyl termini of the three human Atg8 homologues, microtubule-associated protein light chain 3 (LC3), GABARAP, and GATE-16.[2]
The rapid advancement in our understanding of the mechanisms and regulation of
infectious disease
, muscular disorders and possibly will provide therapeutic tools.
See also
References
- ^ Development by self-digestion: molecular mechanisms and biological functions of autophagy by Levine B, Klionsky DJ. in Dev Cell. 2004 Apr;6(4):463-77. Review.
- ^ HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates byTanida I, Sou YS, Ezaki J, Minematsu-Ikeguchi N, Ueno T, Kominami E. in J Biol Chem. 2004 Aug 27;279(35):36268-76
- ^ Autophagy: in sickness and in health by Cuervo AM. in Trends Cell Biol. 2004 Feb;14(2):70-7.