CDP-acylglycerol O-arachidonoyltransferase
| CDP-acylglycerol O-arachidonoyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In
enzymology, a CDP-acylglycerol O-arachidonoyltransferase (EC 2.3.1.70) was an enzyme construed to catalyze the chemical reaction
- arachidonoyl-CoA + CDP-acylglycerol CoA + CDP-diacylglycerol
When discovered in 1979, the two
substrates of this enzyme were believed to be arachidonoyl-CoA and CDP-acylglycerol, whereas its two products were CoA and CDP-diacylglycerol.[1]
Such enzyme were describes as
glycerophospholipid metabolism
.
However, no CDP-acylglycerol O-arachidonoyltransferase has been characterized, the reaction demonstrated in 1979 by Thompson and MacDonald was not reproducible. In 1983, W. Thomson retracted his discovery explaining possible contamination of their batch of liponucleotides.[2]
References
- Thompson W, MacDonald G (1979). "Isolation of a specific arachidonoyl coenzyme A: cytidine diphosphate monoacylglycerol acyltransferase". J. Biol. Chem. 254 (9): 3311–4. PMID 429352.
