FKBP4
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| Location (UCSC) | Chr 12: 2.79 – 2.81 Mb | Chr 6: 128.41 – 128.42 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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FK506-binding protein 4 is a protein that in humans is encoded by the FKBP4 gene.[5][6]
Function
The protein encoded by this gene is a member of the
phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy.[6]
Structure
This protein contains
PPlase domain
.
Clinical significance
Recent research suggests that FKBP4 may play a role in preventing the
Alzheimer's drugs and for detecting the disease before the onset of clinical symptoms.[7]
Interactions
FKBP4 has been shown to
See also
- Glucocorticoid receptor
- Immunophilins
- FKBP5
- FKBP3 - A DNA binding FKBP. [10]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000004478 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030357 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1279700.
- ^ a b "Entrez Gene: FKBP4 FK506 binding protein 4, 59kDa".
- PMID 25628064.
- PMID 8955134.
- S2CID 20617551.
- PMID 26762975.
Further reading
- Schiene-Fischer C, Yu C (April 2001). "Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases". FEBS Letters. 495 (1–2): 1–6. S2CID 42263861.
- Yem AW, Tomasselli AG, Heinrikson RL, Zurcher-Neely H, Ruff VA, Johnson RA, Deibel MR (February 1992). "The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13". The Journal of Biological Chemistry. 267 (5): 2868–71. PMID 1371107.
- Tai PK, Albers MW, Chang H, Faber LE, Schreiber SL (May 1992). "Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex". Science. 256 (5061): 1315–8. PMID 1376003.
- Wiederrecht G, Hung S, Chan HK, Marcy A, Martin M, Calaycay J, Boulton D, Sigal N, Kincaid RL, Siekierka JJ (October 1992). "Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex". The Journal of Biological Chemistry. 267 (30): 21753–60. PMID 1383226.
- Sanchez ER, Faber LE, Henzel WJ, Pratt WB (May 1990). "The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins". Biochemistry. 29 (21): 5145–52. PMID 2378870.
- Alnemri ES, Fernandes-Alnemri T, Nelki DS, Dudley K, DuBois GC, Litwack G (July 1993). "Overexpression, characterization, and purification of a recombinant mouse immunophilin FKBP-52 and identification of an associated phosphoprotein". Proceedings of the National Academy of Sciences of the United States of America. 90 (14): 6839–43. PMID 8341706.
- Chambraud B, Radanyi C, Camonis JH, Shazand K, Rajkowski K, Baulieu EE (December 1996). "FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin". The Journal of Biological Chemistry. 271 (51): 32923–9. PMID 8955134.
- Bruner KL, Derfoul A, Robertson NM, Guerriero G, Fernandes-Alnemri T, Alnemri ES, Litwack G (1998). "The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52". Receptors & Signal Transduction. 7 (2): 85–98. PMID 9392437.
- Miyata Y, Chambraud B, Radanyi C, Leclerc J, Lebeau MC, Renoir JM, Shirai R, Catelli MG, Yahara I, Baulieu EE (December 1997). "Phosphorylation of the immunosuppressant FK506-binding protein FKBP52 by casein kinase II: regulation of HSP90-binding activity of FKBP52". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14500–5. PMID 9405642.
- Bermingham NA, Rauf S, Katsanis N, Martin JE, Hunter AJ, Fisher EM (March 1998). "The immunophilin FKBP4 (FKBP52/FKBP59) maps to the distal short arm of human chromosome 12". Mammalian Genome. 9 (3): 268. S2CID 8388657.
- Chambraud B, Radanyi C, Camonis JH, Rajkowski K, Schumacher M, Baulieu EE (March 1999). "Immunophilins, Refsum disease, and lupus nephritis: the peroxisomal enzyme phytanoyl-COA alpha-hydroxylase is a new FKBP-associated protein". Proceedings of the National Academy of Sciences of the United States of America. 96 (5): 2104–9. PMID 10051602.
- Mamane Y, Sharma S, Petropoulos L, Lin R, Hiscott J (February 2000). "Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52". Immunity. 12 (2): 129–40. PMID 10714679.
- Neye H (March 2001). "Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts the interaction with FKBP12 and FKBP52". Regulatory Peptides. 97 (2–3): 147–52. S2CID 20617551.
- Galigniana MD, Radanyi C, Renoir JM, Housley PR, Pratt WB (May 2001). "Evidence that the peptidylprolyl isomerase domain of the hsp90-binding immunophilin FKBP52 is involved in both dynein interaction and glucocorticoid receptor movement to the nucleus". The Journal of Biological Chemistry. 276 (18): 14884–9. PMID 11278753.
- Qing K, Hansen J, Weigel-Kelley KA, Tan M, Zhou S, Srivastava A (October 2001). "Adeno-associated virus type 2-mediated gene transfer: role of cellular FKBP52 protein in transgene expression". Journal of Virology. 75 (19): 8968–76. PMID 11533160.
- Guo Y, Guettouche T, Fenna M, Boellmann F, Pratt WB, Toft DO, Smith DF, Voellmy R (December 2001). "Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex". The Journal of Biological Chemistry. 276 (49): 45791–9. PMID 11583998.
- Davies TH, Ning YM, Sánchez ER (February 2002). "A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins". The Journal of Biological Chemistry. 277 (7): 4597–600. PMID 11751894.
External links
- FKBP52 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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