Intracrine
Intracrine refers to a
Paracrine physiology has been understood for decades now and the effects of paracrine hormones have been observed when for example, an obesity associate tumor will face the effects of local adipocytes, even if it is not in direct contact with the fat pads in concern.[1] Endocrine physiology on the other hand is a growing field and has had a new area explored, called intracrinology. In intracrinology, the sex steroids produced locally, exert their action in the same cell where they are produced.[2]
The biological effects produced by intracellular actions are referred as intracrine effects, whereas those produced by binding to cell surface receptors are called endocrine,
Intracrine can also refer to a hormone acting within the cell that synthesizes it.
Examples of intracrine peptide hormones: There are several protein/peptide hormones that are also intracrines. Notable examples that have been described in the references include:
- Peptides of the angiotensin II and angiotensin (1-7)
- Fibroblast growth factor 2
- Parathyroid hormone-related protein
See also
- Local hormone
- Autocrine signalling
References
- Park, Jiyoung; Euhus, David M.; Scherer, Philipp E. (August 2011). "Paracrine and Endocrine Effects of Adipose Tissue on Cancer Development and Progression". Endocrine Reviews. 32 (4): 550–570. .
- Labrie, Fernand; Luu-The, Van; Labrie, Claude; Bélanger, Alain; Simard, Jacques; Lin, Sheng-Xiang; Pelletier, Georges (April 2003). "Endocrine and Intracrine Sources of Androgens in Women: Inhibition of Breast Cancer and Other Roles of Androgens and Their Precursor Dehydroepiandrosterone". Endocrine Reviews. 24 (2): 152–182. .
- Re, RN (Apr 2003). "The intracrine hypothesis and intracellular peptide hormone action". BioEssays. 25 (4): 401–9. PMID 12655647.
- Re RN (Jan 2002). "The origins of intracrine hormone action". American Journal of the Medical Sciences. 323 (1): 43–8. PMID 11814142.
- Kumar R, Singh VP, Baker KM (July 2007). "The intracellular renin–angiotensin system: a new paradigm". Trends in Endocrinology & Metabolism. 18 (5): 208–214. S2CID 24041932.
- Fiaschi-Taesch NM, Stewart AF (Feb 2003). "Minireview: parathyroid hormone-related protein as an intracrine factor–trafficking mechanisms and functional consequences". Endocrinology. 144 (2): 407–11. PMID 12538599.
- Sorensen V, Nilsen T, Wiedlocha A (May 2006). "Functional diversity of FGF-2 isoforms by intracellular sorting". BioEssays. 28 (5): 504–14. PMID 18296558.
- Specific