Signal transducing adaptor protein
This article needs additional citations for verification. (November 2007) |
Signal transducing adaptor proteins (STAPs) are
Grb2 and SHC1
.
Signaling components
Much of the specificity of
protein kinases and G-protein GTPases into short-lived active complexes in response to an activating signal such as a growth factor binding to its receptor
.
Domains
Adaptor proteins usually contain several domains within their structure (e.g.,
phosphotyrosine residues and SH3 domains recognise proline
-rich sequences within specific peptide sequence contexts of proteins.
There are many other types of interaction domains found within adaptor and other signalling proteins that allow a rich diversity of specific and coordinated protein–protein interactions to occur within the cell during signal transduction.
Examples of adaptor proteins
Adaptor proteins include:
- BCAR3 – Breast cancer anti-estrogen resistance protein 3
- CBL – Casitas B-lineage Lymphoma
- FRS2 – Fibroblast growth factor receptor substrate 2
- GAB2 – GRB2-associated binding protein 2
- GRAP – GRB2-related adaptor protein
- GRAP2 – GRB2-related adaptor protein 2
- GRB2 – Growth factor receptor-bound protein 2
- IRS1– Insulin receptor substrate 1
- LDLRAP1– low-density lipoprotein receptor adaptor protein 1
- MYD88 - Myeloid differentiation primary response gene 88
- NCDN - Neurochondrin
- NCK1 – NCK adaptor protein 1
- NCK2 – NCK adaptor protein 2
- NOS1AP – nitric oxide synthase 1 (neuronal) adaptor protein
- PIK3AP1 – phosphoinositide-3-kinase adaptor protein 1
- SH2B1 – SH2B adaptor protein 1
- SH2B2 – SH2B adaptor protein 2
- SH2B3 – SH2B adaptor protein 3
- SH2D3A -SH2 domain containing 3A
- SH2D3C – SH2 domain containing 3C
- SNTA1– Syntrophin, alpha 1
- SHB – Src homology 2 domain containing adaptor protein B
- SLC4A1AP – solute carrier family 4 (anion exchanger), member 1, adaptor protein
See also
- Wikipedia:MeSH D12.776#MeSH D12.776.157.057 --- adaptor proteins.2C signal transducing
- Wikipedia:MeSH D12.776#MeSH D12.776.543.990.150 --- adaptor proteins.2C vesicular transport
References
- ^ "Role of Signal Transducing Adaptor Protein (STAP) Family in Chronic Myelogenous Leukemia". Retrieved 24 August 2018.
- ^ Signal+Transducing+Adaptor+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ^ "Entrez Gene: MYD88 Myeloid differentiation primary response gene (88)".
- S2CID 44843127.
Further reading
- TAB2 is an adaptor protein involved in the PMID 10882101.
- Good article about adaptor proteins involved in PMID 11607837.
- A good article regarding the role of adaptor proteins involved with the PMID 11861607.
- Signalling discussed with regards to adaptor proteins: Pawson, T. (1997). "Signaling Through Scaffold, Anchoring, and Adaptor Proteins". Science. 278 (5346): 2075–2080. PMID 9405336.