Leukotriene-E4 20-monooxygenase
| leukotriene-E4 20-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In
enzymology, a leukotriene-E4 20-monooxygenase (EC 1.14.13.34) is an enzyme that catalyzes the chemical reaction
- (7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14- tetraenoate + NADPH + H+ + O2 20-hydroxyleukotriene E4 + NADP+ + H2O
The 5
substrates of this enzyme are (7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-, tetraenoate, NADPH, H+, and O2, whereas its 3 products are 20-hydroxyleukotriene E4, NADP+, and H2O
.
This enzyme belongs to the family of
arachidonic acid metabolism
.
References
- Orning L (December 1987). "Omega-oxidation of cysteine-containing leukotrienes by rat-liver microsomes. Isolation and characterization of omega-hydroxy and omega-carboxy metabolites of leukotriene E4 and N-acetylleukotriene E4". European Journal of Biochemistry. 170 (1–2): 77–85. PMID 2826163.
