Pancreatic serous cystadenoma

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Pancreatic serous cystadenoma
Other namesSerous cystadenoma of the pancreas, serous microcystic adenoma
Micrograph showing a pancreatic serous cystadenoma. H&E stain.
SpecialtyGeneral surgery, gastroenterology
SymptomsUsually asymptomatic
Usual onset50–60 years of age
Risk factorsFemale gender
TreatmentSurgical resection (if symptomatic)
Deaths0.1%[1]

Pancreatic serous cystadenoma is a

von Hippel–Lindau syndrome.[2]

In contrast to some of the other cyst-forming tumors of the pancreas (such as the intraductal papillary mucinous neoplasm and the pancreatic mucinous cystadenoma), serous cystic neoplasms are almost always entirely benign. There are some exceptions; rare case reports have described isolated malignant serous cystadenocarcinomas.[3] In addition, serous cystic neoplasms slowly grow, and if they grow large enough they can press on adjacent organs and cause symptoms.

Signs and symptoms

In most cases, serous cystadenomas of the pancreas are asymptomatic.[4] However, large cysts may cause symptoms related to their size.[4]

Classification

Pathologists classify serous cystic neoplasms into two broad groups. Those that are benign, that have not spread to other organs, are designated "serous cystadenoma".[5] Serous cystadenomas can be further sub-typed into microcystic, oligocystic (or macrocystic), solid, mixed serous-endocrine neoplasm, and VHL-associated serous cystic neoplasm. This latter classification scheme is useful because it highlights the range of appearances and the clinical associations of these neoplasms. Serous cystic neoplasms that have spread ("metastasized") to another organ are considered malignant and are designated "serous cystadenocarcinoma".[citation needed
]

Pathology

Treatment

These lesions rarely require

distal pancreatectomy), or rarely removal of the entire pancreas (a total pancreatectomy).[6] In selected cases the surgery can be performed using minimally invasive techniques such as laparoscopy.[7]

Epidemiology

Relative incidences of various pancreatic neoplasms, with serous cystadenoma annotated near bottom right.[8]

Serous cystadenomas of the pancreas are more common in women.[4] SCAs are usually diagnosed in people 50–60 years of age.[4]

See also

References

  1. S2CID 206962150
    .
  2. ^
    ISBN 978-92-832-4499-8.{{cite book}}: CS1 maint: location missing publisher (link
    )
  3. S2CID 32023143
    .
  4. ^
    S2CID 3584079
    .
  5. ^ "Pathology of Neoplasms of the Pancreas". Johns Hopkins University. Retrieved 25 April 2010.
  6. ^ "Pancreatic Surgery". Johns Hopkins University. Retrieved 25 April 2010.
  7. ^ "Laproscopic Pancreatic Surgery". Johns Hopkins University. Retrieved 25 April 2010.
  8. PMID 21721197.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
    Diagram by Mikael Häggström, M.D.

External links
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