Bromazine

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Bromazine
Clinical data
Trade namesAmbodryl, Ambrodil, Deserol
Other namesBromodiphenhydramine; Bromdiphenhydramine
MedlinePlusa682065
Routes of
administration
Oral
ATC code
Pharmacokinetic data
BioavailabilityHigh
Protein binding96%
MetabolismMostly hepatic (CYP-mediated), also renal
Elimination half-life1 to 4 hours
Identifiers
  • 2-[(4-Bromophenyl)-phenylmethoxy]-N,N-dimethylethanamine
JSmol)
  • Brc1ccc(cc1)C(OCCN(C)C)c2ccccc2
  • InChI=1S/C17H20BrNO/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15/h3-11,17H,12-13H2,1-2H3 checkY
  • Key:NUNIWXHYABYXKF-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Bromazine, sold under the brand names Ambodryl, Ambrodil, and Deserol among others, also known as bromodiphenhydramine, is an

phenyl rings.[1][2]

Synthesis

Synthesis:[6] Patent:[7]

Grignard reaction between

deanol
completed the synthesis of Bromazine (4).

Side effects

Continuous and/or cumulative use of

cognitive decline and dementia in elderly people.[8][9]

References

  1. ^ .
  2. ^ .
  3. ^ Baker CE (1974). Physicians' Desk Reference (28th ed.). Oradell, NJ 07649: Medical Economics Company. pp. 1076, 1081.{{cite book}}: CS1 maint: location (link)
  4. PMID 23173575
    .
  5. .
  6. .
  7. ^ US 2527963, Rieveschl Jr G, "Beta-dimethylamino-ethyl rho-halobenzhydryl ethers and their salts", issued 31 October 1950, assigned to Parke Davis & Co. 
  8. PMID 25621434
    .
  9. .