SOCS2
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| Location (UCSC) | Chr 12: 93.57 – 93.58 Mb | Chr 10: 95.22 – 95.25 Mb | |||||||
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Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.[5][6][7]
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as
interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling.[8] Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.[7][9]
Interactions
SOCS2 has been shown to
E3 ubiquitin ligase complex.[11] It is under investigation for use in targeted protein degradation.[12]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000120833 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020027 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9344848.
- PMID 9266833.
- ^ a b "Entrez Gene: SOCS2 suppressor of cytokine signaling 2".
- ^ PMID 9727029.
- PMID 12040024.
- S2CID 10228882.
- PMID 31182716.
- PMID 37816714.
Further reading
- Lopaczynski W (1999). "Differential regulation of signaling pathways for insulin and insulin-like growth factor I". Acta Biochimica Polonica. 46 (1): 51–60. PMID 10453981.
- Wang J, Campbell IL (February 2002). "Cytokine signaling in the brain: putting a SOCS in it?". Journal of Neuroscience Research. 67 (4): 423–427. S2CID 33269663.
- Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (May 2002). "The SOCS box: a tale of destruction and degradation". Trends in Biochemical Sciences. 27 (5): 235–241. PMID 12076535.
- Pezet A, Buteau H, Kelly PA, Edery M (May 1997). "The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor". Molecular and Cellular Endocrinology. 129 (2): 199–208. S2CID 10606236.
- Dey BR, Spence SL, Nissley P, Furlanetto RW (September 1998). "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor". The Journal of Biological Chemistry. 273 (37): 24095–24101. PMID 9727029.
- Pezet A, Favre H, Kelly PA, Edery M (August 1999). "Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling". The Journal of Biological Chemistry. 274 (35): 24497–24502. PMID 10455112.
- Yandava CN, Pillari A, Drazen JM (October 1999). "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively". Genomics. 61 (1): 108–111. PMID 10512686.
- Ram PA, Waxman DJ (December 1999). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms". The Journal of Biological Chemistry. 274 (50): 35553–35561. PMID 10585430.
- Metcalf D, Greenhalgh CJ, Viney E, Willson TA, Starr R, Nicola NA, et al. (June 2000). "Gigantism in mice lacking suppressor of cytokine signalling-2". Nature. 405 (6790): 1069–1073. S2CID 13750159.
- Shen X, Hong F, Nguyen VA, Gao B (September 2000). "IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3". FEBS Letters. 480 (2–3): 132–136. S2CID 84290049.
- Eyckerman S, Verhee A, der Heyden JV, Lemmens I, Ostade XV, Vandekerckhove J, Tavernier J (December 2001). "Design and application of a cytokine-receptor-based interaction trap". Nature Cell Biology. 3 (12): 1114–1119. S2CID 10228882.
- Schultheis B, Carapeti-Marootian M, Hochhaus A, Weisser A, Goldman JM, Melo JV (March 2002). "Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: possible inadequacy of a negative feedback mechanism". Blood. 99 (5): 1766–1775. PMID 11861294.
- Blumenstein M, Bowen-Shauver JM, Keelan JA, Mitchell MD (March 2002). "Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of labor". The Journal of Clinical Endocrinology and Metabolism. 87 (3): 1094–1097. PMID 11889171.
- Biener E, Maurice S, Sandowski Y, Cohen Y, Gusakowsky EE, Hooghe R, et al. (July 2002). "Recombinant human CIS2 (SOCS2) protein: subcloning, expression, purification, and characterization". Protein Expression and Purification. 25 (2): 305–312. PMID 12135564.
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External links
- SOCS2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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