Sodium picosulfate

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Sodium picosulfate
Ball-and-stick model of the component ions of sodium picosulfate
Clinical data
Other namesPicosulfuric acid
AHFS/Drugs.comInternational Drug Names
License data
By mouth
ATC code
Legal status
Legal status
Identifiers
  • disodium (pyridin-2-ylmethylene)di-4,1-phenylene disulfate
JSmol)
  • monohydrate: O.[Na+].[Na+].[O-]S(=O)(=O)OC1=CC=C(C=C1)C(C1=CC=C(OS([O-])(=O)=O)C=C1)C1=CC=CC=N1

  • anhydrous: [Na+].[Na+].[O-]S(=O)(=O)OC1=CC=C(C=C1)C(C1=CC=C(OS([O-])(=O)=O)C=C1)C1=CC=CC=N1
  • monohydrate: InChI=1S/C18H15NO8S2.2Na.H2O/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;;1H2/q;2*+1;/p-2
  • Key:FHYUVJHZGPGDSP-UHFFFAOYSA-L ☒N

  • anhydrous: InChI=1S/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2 ☒N
  • Key:GOZDTZWAMGHLDY-UHFFFAOYSA-L
 ☒NcheckY (what is this?)  (verify)

Sodium picosulfate (

stimulant laxative used as a treatment for constipation or to prepare the large bowel before colonoscopy or surgery
.

It is available as a

generic medication.[2]

Medical uses

Sodium picosulfate used in combination with magnesium oxide and anhydrous citric acid is

indicated for cleansing of the colon as a preparation for colonoscopy.[1]

Effects

Orally administered sodium picosulfate is generally used for thorough evacuation of the bowel, usually for patients who are preparing to undergo a colonoscopy. It takes 12–24 hours to work, since it works in the colon.[3]

Abdominal cramps and diarrhea are normal effects of picosulfate and should be expected.

The use of sodium picosulfate has also been associated with certain

electrolyte disturbances, such as hyponatremia and hypokalemia.[4]
Patients are often required to drink large amounts of clear fluids, to compensate for dehydration and to reestablish normal electrolyte balance.

Mechanism of action

Sodium picosulfate is a

stimulant laxative and increases peristalsis in the gut.[5][7]

Sodium picosulfate is typically prescribed in a combined formulation with

osmotic laxative. This combination is a highly effective laxative, often prescribed to patients for bowel cleansing prior to colonoscopies.[5][8]

Society and culture

Brand names

It is sold under the brand names Sodipic Picofast, Laxoberal, Laxoberon,[9] Purg-Odan, Picolax, Guttalax, Namilax, Pico-Salax,[10] PicoPrep,[11] and Prepopik,[3] among others.

Clenpiq is a combination of sodium picosulfate, magnesium oxide, and citric acid.[1]

References

  1. ^ a b c "Clenpiq- sodium picosulfate, magnesium oxide, and anhydrous citric acid liquid". DailyMed. 5 September 2023. Retrieved 30 December 2023.
  2. ^ "2022 First Generic Drug Approvals". U.S. Food and Drug Administration (FDA). 3 March 2023. Archived from the original on 30 June 2023. Retrieved 30 June 2023.
  3. ^ a b "FDA News Release – FDA approves new colon-cleansing drug for colonoscopy prep". Food and Drug Administration. 17 July 2012. Retrieved 1 December 2016.
  4. ^ ADRAC (February 2002). "Electrolyte disturbances with sodium picosulfate bowel cleansing products". Aust Adv Drug React Bull. 21 (1). Free full text Archived 22 April 2011 at the Wayback Machine from the Australian Therapeutic Goods Administration
  5. ^
    PMID 21162694
    .
  6. S2CID 13177533
    .
  7. PMID 1243088
    .
  8. S2CID 7579449
    .
  9. ^ Website of Merck Pakistan
  10. ^ PICO SALAX Product Information Archived 22 March 2012 at the Wayback Machine
  11. S2CID 36729352
    .
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