Spermatogonium

Source: Wikipedia, the free encyclopedia.
Spermatogonium
capillaries
Identifiers
MeSHD013093
FMA72291
Anatomical terminology]

A spermatogonium (pl.: spermatogonia) is an undifferentiated male germ cell. Spermatogonia undergo spermatogenesis to form mature spermatozoa in the seminiferous tubules of the testis.

There are three subtypes of spermatogonia in humans:

Anticancer drugs

Anticancer drugs such as doxorubicin and vincristine can adversely affect male fertility by damaging the DNA of proliferative spermatogonial stem cells. Experimental exposure of rat undifferentiated spermatogonia to doxorubicin and vincristine indicated that these cells are able to respond to DNA damage by increasing their expression of DNA repair genes, and that this response likely partially prevents DNA break accumulation.[2] In addition to a DNA repair response, exposure of spermatogonia to doxorubicin can also induce programmed cell death (apoptosis).[3]

Additional images

  • Transverse section of a tubule of the testis of a rat. X 250.
    Transverse section of a
    testis of a rat
    . X 250.
  • Schematic diagram of Spermatocytogenesis Wandimu Geneti
    Schematic diagram of Spermatocytogenesis Wandimu Geneti

See also

References