Taxadien-5alpha-ol O-acetyltransferase

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taxadien-5-alpha-ol O-acetyltransferase
Identifiers
ExPASy
NiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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In

enzymology, a taxadien-5alpha-ol O-acetyltransferase (EC 2.3.1.162) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + taxa-4(20),11-dien-5alpha-ol CoA + taxa-4(20),11-dien-5alpha-yl acetate

Thus, the two

.

This enzyme participates in

diterpenoid biosynthesis
.

Nomenclature

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:taxa-4(20),11-dien-5alpha-ol O-acetyltransferase. Other names in common use include acetyl coenzyme A:taxa-4(20),11(12)-dien-5alpha-ol O-acetyl, and transferase.

References

Further reading

  • Walker K, Ketchum RE, Hezari M, Gatfield D, Goleniowski M, Barthol A, Croteau R (April 1999). "Partial purification and characterization of acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase that catalyzes the first acylation step of taxol biosynthesis". Archives of Biochemistry and Biophysics. 364 (2): 273–9.
    PMID 10190984
    .