Thyroid lymphoma
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| Thyroid lymphoma | |
|---|---|
ENT surgery, endocrinology, oncology | |
Thyroid lymphoma is a rare
Signs and symptoms
As with other thyroid lesions, thyroid lymphoma affects predominantly females over 70 years of age with a history of Hashimoto's thyroiditis. Thus, Hashimoto's thyroiditis is considered a risk factor for thyroid lymphoma development. Thyroid lymphoma manifests as a rapidly enlarging neck mass which may compress the nearby trachea thereby causing narrowing or obstruction of the airway resulting in breathing difficulties or even respiratory failure. On physical examination, affected people typically exhibit a firm thyroid gland and enlarged lymph nodes.[citation needed]
- Painless neck mass
- Hoarseness
- Difficulty swallowing
- Signs of tracheal compression
Diagnosis
Thyroid lymphoma poses a diagnostic and therapeutic challenge. This is because several manifestation patterns are similar to those of anaplastic thyroid cancer (ATC). Fine-needle aspiration (FNA) helps distinguish the two entities preoperatively.[citation needed]
Histopathology
The majority of thyroid lymphomas are non–Hodgkin's B-cell lymphomas; a minority exhibit
- Diffuse large B-cell lymphoma with marginal zone
- Diffuse large B-cell lymphoma without marginal zone
- Marginal zone В-cell lymphoma of mucosa-associated lymphoid tissue(MALT)
- Follicular lymphoma
Staging
Staging of thyroid lymphoma is shown in the table below[citation needed]
| Stage | Characteristics |
|---|---|
| 1Е | Lymphoma is located within the thyroid |
| 2Е | Lymphoma is located within the thyroid and regional lymph-nodes |
| 3Е | Lymphoma is located at both sides of diaphragm |
| 4Е | Dissemination of lymphoma |
Treatment
Combined modality therapy is the most common approach for the initial treatment of thyroid lymphomas. The CHOP regimen (
Prognosis
The factors of poor prognosis for people with thyroid lymphoma are advanced stage of the tumor, large size (>10 cm) as well as spreading to mediastinum. The overall survival for primary thyroid lymphoma is 50% to 70%, ranging from 80% in stage IE to less than 36% in stage IIE and IVE in 5 years.[5][2][citation needed]