Toxic granulation
Toxic granulation refers to dark coarse granules found in
granulocytes, particularly neutrophils, in patients with inflammatory conditions.[1]
Clinical significance
Along with
Composition
Toxic granules are mainly composed of
promyelocytes.[4][5] Although normal, mature neutrophils do contain some primary granules, the granules are difficult to identify by light microscopy because they lose their dark blue colour as the cells mature. Toxic granulation thus represents abnormal maturation of neutrophils.[6]
Similar conditions
Patients with the inherited condition
Alder-Reilly anomaly exhibit very large, darkly staining granules in their neutrophils, which can be confused with toxic granulation.[2][7]
See also
References
- ^ American Association for Clinical Chemistry (2018-12-09). "Blood Smear". Lab Tests Online. Retrieved 2019-07-30.
- ^ ISBN 978-0-7020-6925-3.
- ^ ISBN 978-0-8036-1732-2.
- ISBN 978-0-7020-4535-6.
- S2CID 35344507.
- ISBN 978-0-930304-66-9.
- ISBN 978-0-7817-6507-7.