Pappenheimer bodies
Pappenheimer bodies are abnormal basophilic granules of iron found inside red blood cells on routine blood stain.[1] They are a type of
A cell containing Pappenheimer bodies is a siderocyte. Reticulocytes often contain Pappenheimer bodies. They are mostly observed in diseases such as myelodysplastic syndrome (MDS), sideroblastic anemia, hemolytic anemia, lead poisoning and sickle cell disease. They can interfere with platelet counts when the analysis is performed by electro-optical counters.[2]
Distinction with basophilic stippling
Pappenheimer bodies must be distinguished with other basophilic granules inside erythrocytes like the basophilic stippling. Contrary to the latter, they contain iron.[3]
History
In 1945, Alwin Max Pappenheimer Jr. et al. described three patients whose red blood cells, after splenectomy, showed inclusions when stained with Giemsa stain or Wright's stain.[4]
Diagnosis
Pappenheimer bodies are visible with a Wright and/or Giemsa stain. Confirmation of non-heme iron in the granules is made with a
References
- PMID 15054821.
- ^ "Definition: Pappenheimer bodies from Online Medical Dictionary". Retrieved 2008-03-23.
- ISBN 978-1451172683.)
{{cite book}}: CS1 maint: location missing publisher (link - S2CID 88228863.
- ^ "Medical Definition of SIDEROCYTE". www.merriam-webster.com. Retrieved 11 October 2020.
3. Lazarchick, J. "Pappenheimer Bodies." ASH Image Bank (2004);
External links
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- PMID 15054821.