UGT1A3
| UGT1A3 | |||
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Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| Location (UCSC) | Chr 2: 233.73 – 233.77 Mb | Chr 1: 88.13 – 88.15 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
UDP-glucuronosyltransferase 1-3 is an enzyme that in humans is encoded by the UGT1A3 gene.[5][6][7]
This gene encodes a UDP-
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000288702 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090171 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Gene: UGT1A3 (ENSG00000243135) - Summary - Homo sapiens - Ensembl genome browser 89". may2017.archive.ensembl.org. Retrieved 2019-05-18.
- ^ "Gene: Ugt1a2 (ENSMUSG00000090171) - Summary - Mus musculus - Ensembl genome browser 89". may2017.archive.ensembl.org. Retrieved 2019-05-18.
- PMID 9295054.
- PMID 1339448.
- PMID 11434514.
- ^ "UGT1A3 UDP glucuronosyltransferase family 1 member A3 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-05-18.
Further reading
- Tukey RH, Strassburg CP (2000). "Human UDP-glucuronosyltransferases: metabolism, expression, and disease". Annual Review of Pharmacology and Toxicology. 40: 581–616. PMID 10836148.
- Tukey RH, Strassburg CP (March 2001). "Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract". Molecular Pharmacology. 59 (3): 405–14. S2CID 21500183.
- King CD, Rios GR, Green MD, Tephly TR (September 2000). "UDP-glucuronosyltransferases". Current Drug Metabolism. 1 (2): 143–61. PMID 11465080.
- Moghrabi N, Sutherland L, Wooster R, Povey S, Boxer M, Burchell B (May 1992). "Chromosomal assignment of human phenol and bilirubin UDP-glucuronosyltransferase genes (UGT1A-subfamily)". Annals of Human Genetics. 56 (2): 81–91. S2CID 40140345.
- Mojarrabi B, Butler R, Mackenzie PI (August 1996). "cDNA cloning and characterization of the human UDP glucuronosyltransferase, UGT1A3". Biochemical and Biophysical Research Communications. 225 (3): 785–90. PMID 8780690.
- Strassburg CP, Manns MP, Tukey RH (July 1997). "Differential down-regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer". Cancer Research. 57 (14): 2979–85. PMID 9230212.
- Strassburg CP, Oldhafer K, Manns MP, Tukey RH (August 1997). "Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue". Molecular Pharmacology. 52 (2): 212–20. S2CID 37098463.
- Strassburg CP, Manns MP, Tukey RH (April 1998). "Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8". The Journal of Biological Chemistry. 273 (15): 8719–26. PMID 9535849.
- Green MD, King CD, Mojarrabi B, Mackenzie PI, Tephly TR (June 1998). "Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3". Drug Metabolism and Disposition. 26 (6): 507–12. PMID 9616184.
- Strassburg CP, Kneip S, Topp J, Obermayer-Straub P, Barut A, Tukey RH, Manns MP (November 2000). "Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine". The Journal of Biological Chemistry. 275 (46): 36164–71. PMID 10748067.
- Barbier O, Albert C, Martineau I, Vallée M, High K, Labrie F, Hum DW, Labrie C, Bélanger A (March 2001). "Glucuronidation of the nonsteroidal antiestrogen EM-652 (SCH 57068), by human and monkey steroid conjugating UDP-glucuronosyltransferase enzymes". Molecular Pharmacology. 59 (3): 636–45. S2CID 38640331.
- Turgeon D, Chouinard S, Belanger P, Picard S, Labbe JF, Borgeat P, Belanger A (June 2003). "Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases". Journal of Lipid Research. 44 (6): 1182–91. PMID 12639971.
- Zhang JY, Zhan J, Cook CS, Ings RM, Breau AP (May 2003). "Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism". Drug Metabolism and Disposition. 31 (5): 652–8. S2CID 23434477.
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