Lactose synthase
| Lactose synthase | |||||||||
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ExPASy NiceZyme view | | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Lactose synthase is an
It is classified under EC 2.4.1.22.
It consists of
N-acetyllactosamine synthase falls under the category of beta-1,4-galactosyltransferase, a type-II membrane protein found in the Golgi.[1][2] Alpha-lactalbumin is a Ca2+ binding protein specific to mammary glands. Beta-1,4-galactosyltransferase consists of the catalytic component and alpha-lactalbumin consists of the regulatory component of lactose synthase.[1] Alpha-lactalbumin promotes glucose binding to beta-1,4-galactosyltransferase.[1][2] The beta-1,4-galactosyltransferase catalytic component consists of two flexible loops: small loop and large loop. The small loop consists of a Trp residue (Trp314) with surrounding glycine residues, meanwhile the large loop makes up amino acid residues 345 to 365. The Trp residue in the small loop moves allowing for the sugar nucleotide to be locked into the binding site. This causes a conformational change in the large loop which then creates sites for oligosaccharide and metal ion binding, and protein-protein interactions for alpha-lactalbumin.[3]
References
External links
- Lactose+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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