Anti-streptolysin O
Anti-streptolysin O (ASO or ASLO) is the antibody made against
Increased levels of ASO titre in the blood could cause damage to the heart and joints. In most cases, penicillin is used to treat patients with increased levels of ASO titre.
Clinical significance
When the body is infected with streptococci, it produces
Since these antibodies are produced as a delayed antibody reaction to the above-mentioned bacteria, there is no normal value. The presence of these antibodies indicates an exposure to these bacteria. However, as many people are exposed to these bacteria and remain asymptomatic, the mere presence of ASO does not indicate disease.
A titre has significance only if it is greatly elevated (> 200), but a rise in titre demonstrated in paired blood samples taken days apart is more informative for diagnosis. The antibody levels begin to rise after 1 to 3 weeks of strep infection, peaks in 3 to 5 weeks and falls back to insignificant levels in 6 months. Values need to be correlated with a clinical diagnosis.[citation needed] The aim is to convert it .
Estimation
It is done by serological methods like latex agglutination or slide agglutination. ELISA may be performed to detect the exact titre value. To detect the titre value, by a non-ELISA method, one has to perform the above agglutination using a serial dilution technique.[citation needed]
Mechanism of action
These antibodies produced against the bacteria cross-react with human antigens (mainly
Antistreptolysin O titre
Antistreptolysin O titre (AS(L)O titer or AS(L)OT) is a measure of the blood plasma levels of antistreptolysin O
A positive test usually is > 200 units/mL,[1] but normal ranges vary from laboratory to laboratory and by age.[2]
The
References
- ^ a b c Antistreptococcal antibody titres. gpnotebook. URL: http://www.gpnotebook.co.uk/cache/-1630535637.htm Archived January 26, 2007, at the Wayback Machine. Accessed on: March 31, 2007.
- S2CID 9111180.
External links
- Antistreptococcal antibody titres - GPnotebook.co.uk.
- Antistreptolysin O Titer Archived 2013-03-21 at the Wayback Machine - medterms.com.
- Antistreptolysin O Titer, Serum
- Streptococcal antibody tests - healthAtoZ.com