Rapid plasma reagin
| Rapid plasma reagin | |
|---|---|
 Treponema pallidum, the bacterium that causes syphilis | |
| Synonyms | RPR titer |
| Purpose | test to indicate a syphilis infection |
The rapid plasma reagin test (RPR test or RPR titer) is a type of
VDRL test). The term reagin means that this test does not look for antibodies against the bacterium itself, Treponema pallidum, but rather for antibodies against substances released by cells when they are damaged by T. pallidum (cardiolipin and lecithin). Traditionally, syphilis serologic testing has been performed using a nontreponemal test (NTT) such as the RPR or VDRL test, with positive results then confirmed using a specific treponemal test (TT) such as TPPA or FTA-ABS. This method is endorsed by the U.S. Centers for Disease Control and Prevention (CDC) and is the standard in many parts of the world. After screening for syphilis, a titer can be used to track the progress of the disease over time and its response to therapy.[1]
Accuracy
The RPR test is an effective
FTA-ABS) are more specific and more expensive. Nontreponemal tests (NTT) measure levels of immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies produced by the host in response to lipoidal material (mostly cardiolipin) released from damaged host cells. It is also generally believed that some cardiolipin is released by the spirochetes.[1]
Alternatives
Another test often used to screen for syphilis is the
Venereal Disease Research Laboratory (VDRL) slide test. However, the RPR test is generally preferred due to its ease of use. Other types of tests are being evaluated as possible alternatives to standard manual RPR testing. One of these alternatives is a fully automated RPR syphilis analyzer.[3] It also returns positive for other, non-venereal treponematoses. It has been recommended that a careful explanation of this fact be included with test results.[4]
References
- ^ PMID 25428245.
- OCLC 70819143.
- ^ "Arlington Scientific | ASI Evolution®| ASI". www.arlingtonscientific.com. Archived from the original on 2019-11-18.
- PMID 25193248.
- Jameson JN, Kasper DL, Harrison TR, Braunwald E, Fauci AS, Hauser SL, Longo DL (2005). Harrison's Principles of Internal Medicine (16th ed.). New York: McGraw-Hill Medical Publishing Division. ISBN 0-07-140235-7.
- Sacher, Ronald A.; McPherson, Richard A.; Campos, Joseph M.; Widmann, Frances K. (2000). Widmann's Clinical Interpretation of Laboratory Tests (2nd ed.). Davis. OCLC 42890290.