Biphenyl synthase

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Biphenyl synthase
Identifiers
ExPASy
NiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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In

enzymology, a biphenyl synthase (EC 2.3.1.177) is an enzyme that catalyzes the chemical reaction
:

3 malonyl-CoA + benzoyl-CoA 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2

Thus, the two

substrates of this enzyme are malonyl-CoA and benzoyl-CoA, whereas its three products are CoA, 3,5-dihydroxybiphenyl, and CO2
.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:benzoyl-CoA malonyltransferase. This enzyme is also called BIS.

References

  • Liu B, Beuerle T, Klundt T, Beerhues L (2004). "Biphenyl synthase from yeast-extract-treated cell cultures of Sorbus aucuparia". Planta. 218 (3): 492–6.
    PMID 14595561
    .