Cation channel superfamily
| Ion channel (eukaryotic) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
TCDB 1.A.1 | | ||||||||||
| OPM superfamily | 8 | ||||||||||
| OPM protein | 2a79 | ||||||||||
| |||||||||||
| Ion channel (bacterial) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OPM protein | 1r3j | ||||||||||
| |||||||||||
The transmembrane cation channel superfamily was defined in
TRP channels. This large group of ion channels apparently includes families 1.A.1, 1.A.2, 1.A.3, and 1.A.4 of the TCDB transporter classification
.
They are described as minimally having two
heterotetramers; where heterotetramers may be encoded as distinct genes or as multiple pore domains within a single polypeptide. The HVCN1 and Putative tyrosine-protein phosphatase proteins do not contain an expected ion conduction pore domain, but rather have homology only to the voltage sensor domain of voltage gated ion channels
.
Human channels with 6 TM helices
Cation
Transient receptor potential
Canonical
Melastatin
Vanilloid
Mucolipin
Ankyrin
TRPP
Calcium
Voltage-dependent
- CACNA1S
Sperm
- CATSPER4
Ryanodine receptor
- RYR3
Potassium
Voltage-gated potassium
Delayed rectifier
- Kvα1.x - )
- Kvα2.x - Shab-related: Kv2.1 (KCNB1), Kv2.2 (KCNB2)
- Kvα3.x - Shaw-related: Kv3.1 (KCNC1), Kv3.2 (KCNC2)
- Kvα7.x: Kv7.1 ()
- Kvα10.x: Kv10.1 (KCNH1)
A-type potassium
- Kvα1.x - Shaker-related: Kv1.4 (KCNA4)
- Kvα3.x - Shaw-related: Kv3.3 (KCNC3), Kv3.4 (KCNC4)
- Kvα4.x - Shal-related: Kv4.1 (KCND1), Kv4.2 (KCND2), Kv4.3 (KCND3)
Outward-rectifying
- Kvα10.x: Kv10.2 (KCNH5)
Inwardly-rectifying
- Kvα11.x - )
Slowly activating
Modifier/silencer
- Kvα5.x: Kv5.1 (KCNF1)
- Kvα6.x: Kv6.1 (KCNG1), Kv6.2 (KCNG2), Kv6.3 (KCNG3), Kv6.4 (KCNG4)
- Kvα8.x: Kv8.1 (KCNV1), Kv8.2 (KCNV2)
- Kvα9.x: Kv9.1 (KCNS1), Kv9.2 (KCNS2), Kv9.3 (KCNS3)
Calcium-activated
BK
- KCa1.1 (BK, Slo1, Maxi-K, KCNMA1)
SK
- KCa2.x: KCa2.1 (KCNN3) - SK3
- KCa3.x: KCa3.1 (KCNN4) - SK4
- KCa4.x: KCa4.1 (KCNT1) - SLACK, KCa4.2 (KCNT2) - SLICK
IK
Other subfamilies
Inward-rectifier potassium
Sodium
- NALCN
- SCN11A
- SLC9A11
Cyclic nucleotide-gated
Proton
Related proteins
- TPTE, part of the larger Voltage sensitive phosphatase family
Human channels with 2 TM helices in each subunit
Potassium
Tandem pore domain potassium channel
- KCNK1; KCNK2; KCNK3; KCNK4; KCNK5; KCNK6; KCNK7; KCNK9; KCNK10; KCNK12; KCNK13; KCNK15; KCNK16; KCNK17; KCNK18
Non-human channels
Two-pore
Pore-only potassium
Ligand-gated potassium
- GluR0[2]
Voltage-gated potassium
- KvAP[3]
Prokaryotic KCa
Voltage and cyclic nucleotide gated potassium
- MlotiK1[16]
Sodium
Non-selective
- NaK[22]
Prokaryotic inward-rectifier potassium
- KirBac[23]
Engineered
References
- S2CID 825973.
- S2CID 4391943.
- S2CID 4347957.
- PMID 8170937.
- S2CID 17880955.
- S2CID 205029269.
- PMID 24126388.
- S2CID 418563.
- PMID 20371380.
- PMID 23085076.
- PMID 21317882.
- PMID 23598339.
- S2CID 205233489.
- PMID 23240087.
- PMID 25826626.
- PMID 18216238.
- S2CID 5721075.
- PMID 21743477.
- PMID 24120938.
- PMID 22678295.
- PMID 23033078.
- S2CID 4355500.
- PMID 11806753.
- PMID 21187421.
- PMID 21933962.
External links
- "Voltage-gated Ion Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2021-04-17. Retrieved 2008-12-16.