KCNK6
| KCNK6 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process |
| ||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt |
| ||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) |
| ||||||||
| Location (UCSC) | Chr 19: 38.32 – 38.33 Mb | Chr 7: 28.92 – 28.93 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Potassium channel subfamily K member 6 is a protein that in humans is encoded by the KCNK6 gene.[5][6][7][8]
This gene encodes K2P6.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K2P6.1, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics.[8]
See also
- Tandem pore domain potassium channel
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000099337 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046410 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 10075682.
- S2CID 84538070.
- S2CID 7356601.
- ^ a b "Entrez Gene: KCNK6 potassium channel, subfamily K, member 6".
Further reading
- Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. S2CID 9682396.
- Mahboubi S, Kaufmann JH (1978). "Intramural duodenal hematoma in children. The role of the radiologist in its conservative management". Gastrointestinal Radiology. 1 (2): 167–71. S2CID 12318832.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Salinas M, Reyes R, Lesage F, et al. (1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem. 274 (17): 11751–60. PMID 10206991.
- Pountney DJ, Gulkarov I, Vega-Saenz de Miera E, et al. (1999). "Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit". FEBS Lett. 450 (3): 191–6. S2CID 42980921.
- Patel AJ, Maingret F, Magnone V, et al. (2000). "TWIK-2, an inactivating 2P domain K+ channel". J. Biol. Chem. 275 (37): 28722–30. PMID 10887187.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Mhatre AN, Li J, Chen AF, et al. (2004). "Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4". J. Neurosci. Res. 75 (1): 25–31. S2CID 19133204.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMID 15489334.
External links
- KCNK6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This membrane protein–related article is a stub. You can help Wikipedia by expanding it. |