KCNA7
| KCNA7 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 19: 49.07 – 49.07 Mb | Chr 7: 45.06 – 45.06 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Potassium voltage-gated channel subfamily A member 7 also known as Kv1.7 is a protein that in humans is encoded by the KCNA7 gene.[5] The protein encoded by this gene is a voltage-gated potassium channel subunit. It may contribute to the cardiac transient outward potassium current (Ito1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000104848 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038201 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 219195192.
- PMID 11343410.
Further reading
- Kashuba VI, Kvasha SM, Protopopov AI, et al. (2001). "Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family". Gene. 268 (1–2): 115–22. PMID 11368907.
- Kalman K, Nguyen A, Tseng-Crank J, et al. (1998). "Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7". J. Biol. Chem. 273 (10): 5851–7. PMID 9488722.
- Ding Q, Zhao YY, Dong LY, et al. (2003). "[Distribution and significance of cSNP in KCNA7 gene as a novel NIDDM candidate gene in the population of northeast China]". Yi Chuan. 25 (2): 129–32. PMID 15639836.
- Bardien-Kruger S, Wulff H, Arieff Z, et al. (2002). "Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI)". Eur. J. Hum. Genet. 10 (1): 36–43. S2CID 8333189.
External links
- Kv1.7+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- KCNA7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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