TRPM2
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| Location (UCSC) | Chr 21: 44.35 – 44.44 Mb | Chr 10: 77.91 – 77.97 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Transient receptor potential cation channel, subfamily M, member 2, also known as TRPM2, is a protein that in humans is encoded by the TRPM2 gene.
Structure
The protein encoded by this gene is a non-selective calcium-permeable
PARP in response to oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.[7]
Function
The TRPM2 gene is highly expressed in the brain and was implicated by both genetic linkage studies in families
The physiological role of TRPM2 is not well understood. It was shown to be involved in
TNF-alpha.[12] A role has been suggested for TRPM2 in activation of NLRP3 inflammasome, the dysregulation of which is strongly associated with a number of auto inflammatory and metabolic diseases, such as gout, obesity and diabetes.[13] In the brain it is involved in the toxicity of amyloid beta, a protein associated with Alzheimer's disease.[14] In 2016, TRPM2 channel was strongly implicated in the detection of non-painful warm stimuli. Chun-Hsiang Tan and Peter McNaughton studied the responses of actual sensory neurons to thermal stimuli, then used an RNA-sequencing strategy to identify TRPM2 as genetically required for warmth detection in the non-noxious range of 33–38 °C.[15]
Clinical significance
TRPM2 expression and function help preserve cancer cell viability.[16] TRPM2 channels are highly expressed in many cancers, notably neuroblastoma.[16]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000142185 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009292 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ PMID 16601673.
- PMID 19171771.
- ^ "Entrez Gene: TRPM2 transient receptor potential cation channel, subfamily M, member 2".
- PMID 9686433.
- S2CID 22030624.
- S2CID 6439507.
- PMID 19382906.
- PMID 18542050.
- PMID 23511475.
- S2CID 23311452.
- PMID 27533035.
- ^ PMID 33092205.
Further reading
- Clapham DE, Julius D, Montell C, Schultz G (2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50. S2CID 17936350.
- Eisfeld J, Lückhoff A (2007). "TRPM2". Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology. Vol. 179. pp. 237–52. PMID 17217061.
External links
- TRPM2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.