TRPC1

TRPC1
Identifiers
Gene ontology
Molecular function	store-operated calcium channel activity transmembrane transporter binding calcium channel activity inositol 1,4,5 trisphosphate binding ion channel activity protein binding cation channel activity
Cellular component	integral component of membrane membrane receptor complex plasma membrane integral component of plasma membrane cation channel complex
Biological process	melanin biosynthetic process regulation of cardiac conduction regulation of cytosolic calcium ion concentration positive regulation of release of sequestered calcium ion into cytosol ion transport response to calcium ion calcium ion transmembrane transport manganese ion transport calcium ion transport transmembrane transport
Sources:Amigo / QuickGO

Ensembl				ENSG00000144935	ENSMUSG00000032839
UniProt	P48995	Q61056
RefSeq (mRNA)	NM_001251845 NM_003304	NM_011643 NM_001311123
RefSeq (protein)	NP_001238774 NP_003295	NP_001298052 NP_035773
Location (UCSC)	Chr 3: 142.72 – 142.81 Mb	Chr 9: 95.59 – 95.63 Mb
PubMed search	[3]	[4]

Wikidata

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Transient receptor potential canonical 1 (TRPC1) is a protein that in humans is encoded by the TRPC1 gene.^[5][6]

Function

TRPC1 is an ion channel located on the plasma membrane of numerous human and animal cell types. ^[7] It is a nonspecific cation channel, which means that both sodium and calcium ions can pass through it. TRPC1 is thought to mediate calcium entry in response to depletion of endoplasmic calcium stores or activation of receptors coupled to the

The TRPC1 protein is widely expressed throughout the mammalian brain and has a similar corticolimbic expression pattern as TRPC4 and TRPC5. [9]^[10] The highest density of TRPC1 protein is found in the lateral septum, an area with dense TRPC4 expression, and hippocampus and prefrontal cortex, areas with dense TRPC5 expression.^[10]

History

TRPC1 was the first mammalian Transient Receptor Potential channel to be identified. In 1995 it was cloned when the research groups headed by Craig Montell and Lutz Birnbaumer were searching for proteins similar to the TRP channel in Drosophila. Together with TRPC3 they became the founding members of the TRPC ion channel family.^[5][6]

Interactions

TRPC1 has been shown to

with:

• HOMER3,^[11]
• Polycystic kidney disease 2,^[12]
• RHOA^[13]
• TRPC3,^[14][15]
• TRPC4,^[14][16] and
• TRPC5.^[14][16]

See also

• TRPC

References

Further reading

• Rychkov G, Barritt GJ (2007). "TRPC1 Ca2+-Permeable Channels in Animal Cells". TRPC1 Ca(2+)-permeable channels in animal cells. Handbook of Experimental Pharmacology. Vol. 179. pp. 23–52.
  PMID 17217049
  .
• Ambudkar IS (Feb 2007). "TRPC1: a core component of store-operated calcium channels". Biochemical Society Transactions. 35 (Pt 1): 96–100.
  PMID 17233611
  .

External links

• TRPC1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• "TRIP Database". a manually curated database of protein-protein interactions for mammalian TRP channels.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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