KCNS3
| KCNS3 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 2: 17.88 – 18.36 Mb | Chr 12: 11.14 – 11.2 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Potassium voltage-gated channel subfamily S member 3 (Kv9.3) is a
Function
Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The Kv9.3 protein (encoded by KCNS3 gene) is not functional by itself[9] but can form functional heteromultimers with Kv2.1 (encoded by KCNB1) and Kv2.2 (encoded by KCNB2) (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins.[8] Heteromeric Kv2.1/Kv9.3 channels form with fixed stoichiometry consisting of three Kv2.1 subunits and one Kv9.3 subunit.[15]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000170745 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043673 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 10484328.
- S2CID 219195192.
- ^ a b "Entrez Gene: KCNS3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3". Retrieved 19 June 2017.
- ^ PMID 9362476.
- ^ PMID 9704029.
- PMID 16815889.
- S2CID 27217929.
- PMID 22937123.
- ^ PMID 24170294.
- S2CID 20997775.
- PMID 15827117.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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